The neuropeptide hormone oxytocin is involved in many processes in our bodies, linking our social lives to our internal states. I started out my career studying primate families, an interest that expanded into the role of oxytocin in family-oriented behaviors such as pair bonding and parenting in prairie voles, humans, and other primates. Starting as a post-doc with Dr. C. Sue Carter, I also became interested in the role of oxytocin during development and the way that we manipulate oxytocin clinically. During that post-doc and then as a faculty member at the University of California, Davis, I have worked on a number of these questions.
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| http://dx.doi.org/10.1016/j.cpnec.2023.100203 | DOI Listing |
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CD38-mediated oxytocin signaling in paraventricular nucleus contributes to empathic pain.
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Empathy plays a crucial role in social communication and the perception of affective states and behavioral processes. In this study, we observed that empathic interaction with a mouse experiencing pain resulted in decreased mechanical pain thresholds and anxiety-like behaviors in its bystander, though the underlying mechanisms remain unknown. We demonstrated that CD38 expression in the paraventricular nucleus (PVN) was upregulated during empathic pain, and the pain and emotions of CD38 knockout (CD38KO) mice as bystanders were not affected.
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Department of Physiology, College of Graduate Studies, Midwestern University, Downers Grove, IL, 60515, USA.
The experience of pregnancy affects uterine function well beyond delivery. We previously demonstrated that the response to oxytocin is more robust in the uteri of proven breeder rats. This study investigates the contribution of T-type calcium channels (TTCCs) and L-type calcium channels (LTCCs) to the distinct response of virgin (V) and proven breeder (PB) rat uteri to oxytocin.
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From the School of Clinical Medicine (Liang, Luo, Jia), Shandong Second Medical University, Weifang, from the Department of Neurology (Liang, Zhao, Lin, Li, Luo, Jia) , Beijing Shijingshan Hospital, Shijingshan Teaching Hospital of Capital Medical University, Beijing, and from the Department of Neurology (Li), Affiliated Hospital of Weifang Medical University, Weifang, China.
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