Investigation of antimicrobial and antioxidant activities of extracts and their effects on gentamicin nephrotoxicity in rats.

This study aims to examine the antimicrobial and antioxidant activities of the aerial parts of extracts (CAE) prepared with different solvents, and how ethanol extract protects them against gentamicin-induced nephrotoxicity. Extracts of aerial parts were obtained from ethanol, water, methanol, chloroform, and hexane solvents. Thirty-two male rats were used and gentamycin-induced nephrotoxicity was utilized as a model. The water extract of exhibited no antimicrobial effect, whereas the methanol one created the highest zone diameter on (26 mm). The methanol extract displayed the highest activity in DPPH and ABTS. The ethanol extract yielded the highest reducing power in the CUPRAC. The water extract had the highest reducing power in the FRAP. Concerning gentamicin-induced renal damage, creatinine and urea levels in the blood were statistically higher in the gentamicin- group compared to the other groups ( < .05). Urea and creatinine levels of the gentamicin- group dropped significantly, indicating that the was effective against renal damage. The sections from kidney tissues in the gentamicin +  group mostly exhibited mild glomerular congestion. Hyaline cast, cytoplasmic vacuolization, necrosis, and apoptosis were not observed. Thanks to treatment, the gentamicin +  suffered less histopathological damage than the gentamicin group did. The results of the present study suggest that CAE can be used as a supportive treatment in people undergoing treatment for nephrotoxicity.