An electrochemical approach in promoting directed C-H alkynylation with terminal alkyne via iridium catalysis is reported. This work employed anodic oxidation of Ir(III) intermediate (characterized by X-ray crystallography) to promote reductive elimination, giving the desired coupling products in good yields (up to 95%) without the addition of any other external oxidants. This transformation is suitable for various directing groups with H as the only by-product, which warrants a high atom economy and practical oxidative C-C bond formation under mild conditions.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10723742PMC
http://dx.doi.org/10.1021/acscatal.0c03207DOI Listing

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