AI Article Synopsis
- Intoxication by colchicine is rare but can lead to severe toxicity or death in about 10% of cases.
- A 50-year-old female experienced symptoms after ingesting 10 mg of colchicine and was initially stable but later developed complications like chest pain and respiratory issues.
- The diagnosis indicated pleural effusion linked to cardiac dysfunction from the colchicine overdose, highlighting the importance of recognizing and managing colchicine toxicity to lower risks of severe health outcomes.
Article Abstract
Intoxication by colchicine is rare, and its rapid recognition is crucial, as severe toxicity or death is reported in 10% of cases. Here, we present the case of a 50-year-old female admitted to the emergency department 24 hours after ingesting 10 mg of colchicine. Upon examination, she was conscious and hemodynamically stable. Analytically, she exhibited leukocytosis with neutrophilia and an elevation of lactate dehydrogenase (LDH). She was initiated on fluid therapy and transferred to the intermediate care unit of medicine. On the third day of hospitalization, she developed anterior chest pain, reduced breath sounds in the right hemithorax, and dullness on percussion. Arterial blood gas analysis showed partial respiratory failure, and chest X-rays and a computed tomography (CT) scan revealed a right-sided pleural effusion. The likely diagnosis was pleural effusion secondary to cardiac dysfunction due to colchicine intoxication. This case aims to describe the potential toxic effects of colchicine in cases of overdose and to reflect on ways to reduce its morbidity and mortality.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10725528 | PMC |
| http://dx.doi.org/10.7759/cureus.48933 | DOI Listing |
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