Two new fungal polyketides with unusual skeleton, collecapsins A and B (-), along with two known macrolactins A and B (-), were isolated from the rice cultures of an endophytic fungus obtained from the fresh Makino. Their structures were established by a combination of NMR, HRESIMS, and IR analysis. The absolute configurations of and were determined on the detailed analysis of the modified Mosher's derivatives' spectra and its key NOEs correlations. In this case, the absolute configurations of all chiral centres of were determined for the first time, showed that is a C-6/C-8 epimer of colletruncoic acid methyl ester. Compounds - demonstrated promising lipid lowing activity the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with IC values of 8.72 and 15.28 μM. Compounds - exhibited antibacterial activity with MIC values ranging from 0.25-25.8 μM.
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