Extracorporeal photopheresis (ECP) has proven effective in the treatment of several diseases, including acute and chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation. In its standard version, ECP requires leukapheresis to obtain a fraction of mononuclear cells. The possibility of using leukapheresis is limited by the requirements for vascular access and the somatic status of the patient. We have developed a new ECP method that does not require leukapheresis. This paper presents a description of two clinical cases of severe refractory GVHD treated by micro-ECP.
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Article Synopsis
- Polymyositis is a rare complication of graft-versus-host disease (GvHD) that primarily affects muscle tissues, particularly in patients after stem cell transplants.
- A 23-year-old male with chronic myeloid leukemia experienced severe muscle weakness and respiratory issues six months post-transplant, leading to the diagnosis of GvHD polymyositis through various tests including muscle biopsies and imaging.
- The patient responded positively to treatments like corticosteroids and extracorporeal photopheresis, underscoring the need for prompt diagnosis and a collaborative approach to managing this condition.
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