Tablets are the most commonly prescribed dosage form for oral drug administration. Historically, improvement of medication adherence of tablets has been facilitated through, for example, the use of smaller tablets, distinctive shaped tablets and sugar-coated tablets. In addition, new formulation technologies such as orally disintegrating tablets (OD tablets), micro tablet-type granules, jellies, and film formulations are making it possible to create more easily ingested dosage forms. We have developed a new oral jelly coating formulation that can be applied to any sized tablet without reducing the size of the formulation. It was found that this new jelly layer formed on the tablet surface improved the tablet's slipperiness with an appropriate amount of water, while ensuring no change in the dissolution profile. In addition, the jelly layer was ensured storage stability over time without affecting the dissolution profile. Although further studies are needed, this coating technology can quickly change the tablet surface to a jelly-like state after the tablet is taken, giving the tablet the same slipperiness as if it were taken in jelly, making it easier to pass through the pharynx, and thus improving medication adherence.
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http://dx.doi.org/10.1248/bpb.b23-00625 | DOI Listing |
Saudi Pharm J
December 2024
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Itraconazole (ITZ) is a highly effective antifungal agent. However, its oral application is associated with systemic toxicity and poor topical use. The present study aims to improve the antifungal activity of ITZ by loading it into bioadhesive niosomes.
View Article and Find Full Text PDFBiomater Sci
December 2024
División de Ciencias e Ingenierías, Universidad de Guanajuato, Lomas del bosque 103, 37150, León, Gto, Mexico.
Repair of damaged or faulty complex modular organs such as the urinary bladder is a current clinical challenge. The design of constructs for reconstructive urological surgery can draw advantage from the bioactivity of natural extracellular matrix (ECM) bioscaffolds, as well as the activity provided by cells seeded into constructs. Considering these benefits, this work compares the performance of pericardial ECM bioscaffolds and constructs seeded with gel-supported urothelial cells in the repair of urinary bladder defects in rabbits.
View Article and Find Full Text PDFFoods
November 2024
Faculty of Food Technology, University of Applied Science Fulda, Leipziger Str. 123, 36037 Fulda, Germany.
Legume proteins are increasingly used in structuring various foods under the influence of heating and stirring energy. Based on available studies, this structuring potential is not yet fully understood. This raises the question of the suitability of legume isolates and concentrates for structuring in emulsion gels and the effect of heat and oil on the gel properties.
View Article and Find Full Text PDFCarbohydr Polym
February 2025
Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai 200072, People's Republic of China. Electronic address:
Sci Adv
December 2024
Department of Biomedical Sciences, City University of Hong Kong, Hong Kong 999077, China.
Hemostatic materials that can rapidly control bleeding without causing secondary damage or sharp pain upon removal are receiving increasing demands in acute trauma treatments and first-aid supplies. Here, we report the development of a dynamic silicone hydrogel coating on medical gauze to enable rapid hemostasis and synergistic anti-blood adhesion properties. The silicone hydrogel can spontaneously form oriented cross-linked structures on fibrous medical gauze through a solution-processing method to achieve macroscopic superhydrophobicity with microscopic surface slipperiness, resulting in excellent anti-blood adhesion with the on-wound peeling force at ~0 millinewton.
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