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Antidiabetic potential of fenugreek (): A magic herb for diabetes mellitus.
Food Sci Nutr
October 2024
Pharmacy Discipline, Life Science School Khulna University Khulna Bangladesh.
Fenugreek () is a widely grown dietary herb in Asia, and its seeds are traditionally used for several diseases, including diabetes. The seeds and leaves possess a variety of compounds that play an important role in regulating their hypoglycemic effect. However, so far, no extensive systematic review exists on its antidiabetic effect, highlighting the molecular mechanisms and isolated compounds.
View Article and Find Full Text PDFAntibody-drug conjugates for hepato-pancreato-biliary malignancies: "Magic bullets" to the rescue?
Cancer Treat Rev
September 2024
Department of Surgery, Metaxa Cancer Hospital, Piraeus 18537, Greece.
Hepato-Pancreato-Biliary (HPB) malignancies constitute a highly aggressive group of cancers that have a dismal prognosis. Patients not amenable to curative intent surgical resection are managed with systemic chemotherapy which, however, confers little survival benefit. Antibody-Drug Conjugates (ADCs) are tripartite compounds that merge the intricate selectivity and specificity of monoclonal antibodies with the cytodestructive potency of attached supertoxic payloads.
View Article and Find Full Text PDF[Up-to-Date on clinical and preclinical studies of psilocybin therapy].
Nihon Yakurigaku Zasshi
June 2024
Department of Chemical Pharmacology, Meijo University.
Major Depressive Disorder (MDD) poses a significant global health burden, with 30-40% patients developing resistance to standard clinical antidepressants, such as selective serotonin reuptake inhibitors and tricyclic antidepressants. In 2016, Carhart-Harris and colleagues reported that psilocybin, the hallucinogenic compound derived from magic mushrooms, exhibits rapid and enduring antidepressant effects in patients with treatment-resistant depression. Subsequent clinical studies have found the therapeutic potential of psilocybin in MDD, depressive episode in bipolar disorder, anorexia, and drug addiction.
View Article and Find Full Text PDFAlzheimer's disease and its treatment-yesterday, today, and tomorrow.
Front Pharmacol
May 2024
Department of Pharmacology and Medical Education, Weill Cornell Medicine-Qatar, Doha, Qatar.
Article Synopsis
- Alois Alzheimer identified the first Alzheimer's disease (AD) patient in 1907, and today AD is the leading form of dementia, affecting over 47 million people worldwide, with projections showing numbers could exceed 130 million by 2050.
- In the U.S., approximately six million individuals currently have AD, with expectations of this number doubling by 2050, alongside nearly 12 million experiencing mild cognitive impairment (MCI), which is a precursor to AD.
- The review discusses the limitations of current drugs for AD, emphasizing that while amyloid-β (Aβ) and tau proteins are potential drug targets, existing anti-Aβ therapies may not be the ultimate solution, suggesting a need for research into alternative treatment strategies
Neural mechanisms of psychedelic visual imagery.
Mol Psychiatry
June 2024
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, VIC, Australia.
Visual alterations under classic psychedelics can include rich phenomenological accounts of eyes-closed imagery. Preclinical evidence suggests agonism of the 5-HT2A receptor may reduce synaptic gain to produce psychedelic-induced imagery. However, this has not been investigated in humans.
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