AI Article Synopsis
- Chronic immobilization stress is linked to various neuropsychiatric disorders, and this study investigated how chia seed oil (CSO) can help mitigate its effects in rats subjected to stress.
- The results showed that CSO treatment significantly reduced stress biomarkers and inflammation, restored neuronal health, and improved gene expression related to brain function when compared to untreated stressed rats.
- The findings suggest that CSO has potential as a treatment for stress-induced brain issues by targeting specific proteins involved in inflammation and cell death, highlighting the need for further research in humans.
Article Abstract
Chronic immobilization stress plays a key role in several neuropsychiatric disorders. This investigation assessed the possible ameliorative effect of chia seed oil (CSO) against the neurodisturbance-induced in rats by chronic immobilization. Rats were randomly allocated into control, CSO (1 ml/kg b.wt./orally), restrained (6 h/day), CSO pre-restraint, and CSO post-restraint for 60 days. Results revealed a significant reduction in serum corticosterone level, gene expression of corticotrophin-releasing factor, pro-inflammatory cytokines, and oxidative biomarkers in restrained rats treated with CSO. The histopathological findings revealed restoring necrosis and neuronal loss in CSO-treated-restraint rats. The immunohistochemical evaluation revealed a significant reduction in the immuno-expression of caspase-3, nuclear factor kappa B, interleukin-6, and cyclooxygenase-2 (COX-2), and an elevation of calbindin-28k and synaptophysin expression compared to non-treated restraint rats. The molecular docking showed the CSO high affinity for several target proteins, including caspase-3, COX-2, corticotropin-releasing hormone binding protein, corticotropin-releasing factor receptors 1 and 2, interleukin-1 receptor types 1 and 2, interleukin-6 receptor subunits alpha and beta. In conclusion, CSO emerges as a promising candidate against stress-induced brain disruptions by suppressing inflammatory/oxidative/apoptotic signaling pathways due to its numerous antioxidant and anti-inflammatory components, mainly α-linolenic acid. Future studies are necessary to evaluate the CSO therapeutic impacts in human neurodisturbances.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10725506 | PMC |
| http://dx.doi.org/10.1038/s41598-023-49061-w | DOI Listing |
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