The emerging and powerful field of spatial pharmacology can map the spatial distribution of drugs and their metabolites, as well as their effects on endogenous biomolecules including metabolites, lipids, proteins, peptides, and glycans, without the need for labeling. This is enabled by mass spectrometry imaging (MSI) that provides previously inaccessible information in diverse phases of drug discovery and development. We provide a perspective on how MSI technologies and computational tools can be implemented to reveal quantitative spatial drug pharmacokinetics and toxicology, tissue subtyping, and associated biomarkers. We also highlight the emerging potential of comprehensive spatial pharmacology through integration of multimodal MSI data with other spatial technologies. Finally, we describe how to overcome challenges including improving reproducibility and compound annotation to generate robust conclusions that will improve drug discovery and development processes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10842749 | PMC |
| http://dx.doi.org/10.1016/j.tips.2023.11.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
"Groupitizing": A Visuo-Spatial and Arithmetic Phenomenon.
Open Mind (Camb)
January 2025
Department of Neuroscience, Psychology, Pharmacology, and Child Health, University of Florence, Florence, Italy.
When objects are grouped in space, humans can estimate numerosity more precisely than when they are randomly scattered. This phenomenon, called groupitizing, is thought to arise from the interplay of two components: the subitizing system which identifies both the number of subgroups and of items within each group, and the possibility to perform basic arithmetic operations on the subitized groups. Here we directly investigate the relative role of these two components in groupitizing via an interference (dual task) paradigm.
View Article and Find Full Text PDFFeature-selective adaptation of numerosity perception.
Proc Biol Sci
January 2025
Department of Neuroscience, Psychology, Pharmacology and Child Health, University of Florence, Florence, Italy.
Perceptual adaptation has been widely used to infer the existence of numerosity detectors, enabling animals to quickly estimate the number of objects in a scene. Here, we investigated, in humans, whether numerosity adaptation is influenced by stimulus feature changes as previous research suggested that adaptation is reduced when the colour of adapting and test stimuli did not match. We tested whether such adaptation reduction is due to unspecific novelty effects or changes of stimuli identity.
View Article and Find Full Text PDFThe Effect of Anthocyanins on Cognition: A Systematic Review and Meta-analysis of Randomized Clinical Trial Studies in Cognitively Impaired and Healthy Adults.
Curr Nutr Rep
January 2025
School of Medical, Indigenous and Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong NSW, Wollongong, 2522, Australia.
Purpose Of The Review: Clinical trials suggest that dietary anthocyanins may enhance cognitive function. This systematic literature review and meta-analysis aimed to identify the effect of anthocyanin on cognition and mood in adults.
Recent Findings: Using a random-effects model, Hedge's g scores were calculated to estimate the effect size.
The neurohormone tyramine stimulates the secretion of an insulin-like peptide from the Caenorhabditis elegans intestine to modulate the systemic stress response.
PLoS Biol
January 2025
Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB) CCT UNS-CONICET, Bahía Blanca, Argentina.
The DAF-2/insulin/insulin-like growth factor signaling (IIS) pathway plays an evolutionarily conserved role in regulating reproductive development, life span, and stress resistance. In Caenorhabditis elegans, DAF-2/IIS signaling is modulated by an extensive array of insulin-like peptides (ILPs) with diverse spatial and temporal expression patterns. However, the release dynamics and specific functions of these ILPs in adapting to different environmental conditions remain poorly understood.
View Article and Find Full Text PDFNeonatal Sevoflurane Exposure Exerts Sex-Specific Effects on Cognitive Function via C3- and TLR4-Related M1/M2 Microglial Cell Polarisation in Rats.
J Cell Mol Med
January 2025
Department of Anesthesia, Fujian Medical University Union Hospital, Fuzhou, China.
In this study, we aimed to explore the sex-specific effects and mechanisms of sevoflurane exposure on the neural development of pubertal rats on the basis of M1/M2 microglial cell polarisation and related signalling pathways. A total of 48 rat pups (24 males and 24 females) were assigned to the 0- or 2-h sevoflurane exposure group on the seventh day after birth. The Morris water maze (MWM) test was subsequently conducted on the 32nd to 38th days after birth.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!