AI Article Synopsis
- - Aortic stenosis (AS) severity is hard to assess due to inconsistent metrics, with flow state being crucial for accurate evaluation.
- - A study analyzed two large cohorts (over 2,000 patients total) and found that both the dimensionless index (DI) and transvalvular flow rate (Q) were significant predictors of mortality in AS patients.
- - The results suggest that using both DI and Q together could improve the diagnosis and prognosis of patients with aortic stenosis.
Article Abstract
Aortic stenosis (AS) is difficult to phenotype. The metrics of severity are frequently discordant, making prognostication challenging. Flow state is central to accurately determining severity. We sought to evaluate the prognostic value of dimensionless index (DI) and transvalvular flow rate (Q) in AS. We evaluated 2 independent, longitudinal registries of ≥ moderate severity AS (aortic valve area ≤1.5 cm or mean gradient ≥20 mm Hg) with complete data follow-up. In the primary cohort (n = 1,104, 77 ± 11 years, 40% female), the DI and Q category significantly predicted mortality (p <0.001) (Figure 1), with the highest risk being low DI and low Q (DI <0.25, Q ≤210 mL/s). In the validation cohort (n = 939, 70 ± 13 years, 42% female), similar results were seen in Kaplan-Meier (p <0.001) and multivariable Cox model analyses (p <0.01). We advocate for wider combined use of DI and Q in AS assessment to augment current diagnostic and prognostic approaches.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10842843 | PMC |
| http://dx.doi.org/10.1016/j.amjcard.2023.12.008 | DOI Listing |
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Article Synopsis
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