Objectives: The aim of this study was to assess the association of genetically determined iron status with the risk for non-alcoholic fatty liver disease (NAFLD) using two-sample Mendelian randomization (MR) analysis.
Methods: We applied single nucleotide polymorphisms (SNPs) associated at genome-wide significance with iron status proxied by serum iron, ferritin, transferrin, and transferrin saturation from the Genetics of Iron status Consortium (N = 48 793), in a genome-wide association study of 1664 NAFLD cases and 400 055 controls from the United Kingdom Biobank. A SNP associated with multiple markers of iron status was only applied to one marker with the strongest association in the main analysis. Their effects on NAFLD were calculated using inverse variance weighting after excluding SNPs associated with alkaline phosphatase and lipid metabolism.
Results: The risk for NAFLD is negatively associated with genetically predicted serum transferrin level with a 20% reduction in NAFLD risk per SD (0.65g/L) increase in transferrin (95% confidence interval [CI], 0.66-0.97), and trending positive association with transferrin saturation (odds ratio [OR], 1.50; 95% CI, 0.96-2.35) but it was not associated with serum iron (OR, 0.90; 95% CI, 0.63-1.29) and ferritin (OR, 1.33; 95% CI, 0.54-3.30).
Conclusions: MR analysis provided evidence that genetically predicted higher serum transferrin, indicating lower iron status, may be protective against NAFLD, whereas higher transferrin saturation, indicating higher iron status, might increase the risk for NAFLD and its pathogenesis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.nut.2023.112295 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The prognostic role of iron deficiency in acute ischemic stroke patients: A prospective multicentric cohort study.
J Neurol Sci
December 2024
Emergency Department, Stroke Unit, Sapienza University of Rome, Rome, Italy. Electronic address:
Background And Aims: Iron deficiency (ID) is a prognostic factor in heart failure and acute coronary syndrome. However, its role in cerebrovascular diseases is controversial. We aimed to determine the impact of ID on the functional outcome of acute ischemic stroke patients.
View Article and Find Full Text PDFDigital Monitoring of Anemia Control Measures in a District Using Anemia Mukt Bharat Health Management Information System Indicators.
Cureus
December 2024
Centre for Population Research, Institute of Economic Growth, Delhi University, New Delhi, IND.
Introduction: Anemia is a severe public health problem in India, affecting more than 50% of individuals across most age groups. The Anemia Mukt Bharat (AMB) program, with a target of a three-percentage point reduction in anemia prevalence per year, developed a monitoring mechanism based on a set of 18 indicators and six key performance indicators (KPIs) derived from routine reporting in the Health Management Information System (HMIS). The study's objective was to assess the status of anemia control measures in the district of Faridabad, Haryana, India, using AMB HMIS indicators from April 2018 to March 2019.
View Article and Find Full Text PDFInfluence of nutritional guidance during pregnancy on nutritional status and pregnancy outcome of pregnant women.
Afr J Reprod Health
December 2024
Department of Gynecology, Nanjing General Hospital of Nanjing Military Command, Jiangsu 210000, China.
This study was an original article, mainly aimed to explore the influence of nutritional guidance during pregnancy on nutritional status and pregnancy outcome of pregnant women. Two hundred (200) pregnant women were admitted to the Nanjing General Hospital of Nanjing Military Command from May 2021 to May 2023. They were randomly sub-divided into a control group and an intervention group.
View Article and Find Full Text PDFModeling Hydrogen Markets: Energy System Model Development Status and Decarbonization Scenario Results.
Energy Clim Chang
December 2024
South China University of Technology, School of Future Technology, 777 Xingye Ave East, Panyu District, Guangzhou, Guangdong, 511442, China.
Hydrogen can be used as an energy carrier and chemical feedstock to reduce greenhouse gas emissions, especially in difficult-to-decarbonize markets such as medium- and heavy-duty vehicles, aviation and maritime, iron and steel, and the production of fuels and chemicals. Significant literature has been accumulated on engineering-based assessments of various hydrogen technologies, and real-world projects are validating technology performance at larger scales and for low-carbon supply chains. While energy system models continue to be updated to track this progress, many are currently limited in their representation of hydrogen, and as a group they tend to generate highly variable results under decarbonization constraints.
View Article and Find Full Text PDFImpact of Small-Quantity Lipid-Based Nutrient Supplements on Pubertal Status of 9-13-Year Olds: A Follow-Up Study of the iLiNS-DYAD-Ghana Trial.
Curr Dev Nutr
December 2024
Department of Population, Family and Reproductive Health, School of Public Health, University of Ghana, Accra, Ghana.
Background: Early and delayed puberty are both associated with adverse health and psychosocial outcomes.
Objectives: We assessed the impact of provision of small-quantity lipid-based nutrient supplement (SQ-LNS) to mothers during pregnancy and 6 mo postpartum and to their children aged 6-18 mo, on pubertal status.
Methods: This study was a follow-up to a partially double-blind randomized controlled trial.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!