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Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species. | LitMetric

AI Article Synopsis

  • GATA6 is crucial for the identity of macrophages in mouse peritoneal cavities, but human peritoneal macrophages show different characteristics, with fewer GATA6 macrophages present.
  • In humans, macrophages more closely resemble a less mature stage found in mice, indicating a significant difference in macrophage development between the species.
  • While there are common features shared by macrophage populations in both mice and humans, the proportions and differentiation stages of these cells vary greatly, especially with human macrophages showing a notable presence of dendritic cell-like cells.

Article Abstract

In mouse peritoneal and other serous cavities, the transcription factor GATA6 drives the identity of the major cavity resident population of macrophages, with a smaller subset of cavity-resident macrophages dependent on the transcription factor IRF4. Here we showed that GATA6 macrophages in the human peritoneum were rare, regardless of age. Instead, more human peritoneal macrophages aligned with mouse CD206 LYVE1 cavity macrophages that represent a differentiation stage just preceding expression of GATA6. A low abundance of CD206 macrophages was retained in C57BL/6J mice fed a high-fat diet and in wild-captured mice, suggesting that differences between serous cavity-resident macrophages in humans and mice were not environmental. IRF4-dependent mouse serous cavity macrophages aligned closely with human CD1cCD14CD64 peritoneal cells, which, in turn, resembled human peritoneal CD1cCD14CD64 cDC2. Thus, major populations of serous cavity-resident mononuclear phagocytes in humans and mice shared common features, but the proportions of different macrophage differentiation stages greatly differ between the two species, and dendritic cell (DC2)-like cells were especially prominent in humans.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10990619PMC
http://dx.doi.org/10.1038/s41590-023-01688-7DOI Listing

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