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Acute and subacute toxic effects of CUMYL-4CN-BINACA on male albino rats. | LitMetric

Acute and subacute toxic effects of CUMYL-4CN-BINACA on male albino rats.

Forensic Toxicol

Department of Criminalistics, Graduate School of Natural and Applied Science, Atatürk University, 25240, Erzurum, Turkey.

Published: July 2024

AI Article Synopsis

  • This study investigates the toxic effects of a novel synthetic cannabinoid on adult male rats, focusing on histopathological, hematological, and biochemical changes after acute and subacute exposure.
  • The cannabinoid was administered at different doses over varying time periods, with observations indicating significant organ damage, particularly in the kidneys, and notable changes in blood parameters and oxidative stress.
  • The findings suggest that the synthetic cannabinoid has detrimental effects on rat health, raising concerns about potential risks for humans if misused.

Article Abstract

Purpose: There is very little information about the toxicological and pathological effects of synthetic cannabinoids, which have cannabis-like properties. This study was carried out to histopathologically, hematologically, and biochemically determine the toxic effects of acute and subacute exposure to a novel synthetic cannabinoid 1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)indazole-3-carboxamide in internal organs of adult male rats.

Methods: The cannabinoid was injected intraperitoneally at three doses (0.5, 1.0, and 2.0 mg/kg, body weight). The cannabinoid was administered to acute groups for 2 days and to subacute groups for 14 days. Observations were made for 14 days and various changes such as mortality, injury, and illness were recorded daily. Hematological and biochemical changes were evaluated and histopathological analyses in lung, liver, and kidney tissues were also performed.

Results: No mortality was observed. It was observed that there were fluctuations in hematological and serum biochemical parameters. Among the oxidative stress parameters, significant decreases in superoxide dismutase, catalase levels and significant increases in lipid peroxidation levels were determined. Serious pathological changes such as necrosis, vacuolation, congestion, and fibrosis were observed in the internal organs in a dose-dependent and time-dependent manner. It was also found that the synthetic cannabinoid triggered apoptosis in the organs. The results demonstrated that the most affected organ by the cannabinoid was the kidney.

Conclusion: This study showed for the first time that CUMYL-4CN-BINACA adversely affects healthy male albino rats. It can be estimated that the abuse of the cannabinoid may harm human health in the same way.

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Source
http://dx.doi.org/10.1007/s11419-023-00676-8DOI Listing

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