Objectives: To study if early initiation of inhaled beclomethasone 1200 mcg in patients with asymptomatic, mild or moderate COVID-19 reduces disease progression to severe COVID-19.
Design: Double-blinded, parallel-groups, randomised, placebo-controlled trial.
Setting: A hospital-based study in Sri Lanka.
Participants: Adults with asymptomatic, mild or moderate COVID-19, presenting within the first 7 days of symptom onset or laboratory diagnosis of COVID-19, admitted to a COVID-19 intermediate treatment centre in Sri Lanka between July and November 2021.
Interventions: All participants received inhaled beclomethasone 600 mcg or placebo two times per day, for 10 days from onset of symptoms/COVID-19 test becoming positive if asymptomatic or until reaching primary endpoint, whichever is earlier.
Primary Outcome Measure: Progression of asymptomatic, mild or moderate COVID-19 to severe COVID-19.
Secondary Outcome Measures: The number of days with a temperature of 38°C or more and the time to self-reported clinical recovery.
Results: A total of 385 participants were randomised to receive beclomethasone(n=193) or placebo(n=192) stratified by age (≤60 or >60 years) and sex. One participant from each arm withdrew from the study. All participants were included in final analysis. Primary outcome occurred in 24 participants in the beclomethasone group and 26 participants in the placebo group (RR 0.90 ; p=0.763). The median time for self-reported clinical recovery in all participants was 5 days (95% CI 3 to 7) in the beclomethasone group and 5 days (95% CI 3 to 8) in the placebo group (p=0.5). The median time for self-reported clinical recovery in patients with moderate COVID-19 was 5 days (95% CI 3 to 7) in the beclomethasone group and 6 days (95% CI 4 to 9) in the placebo group (p=0.05). There were no adverse events.
Conclusions: Early initiation of inhaled beclomethasone in patients with asymptomatic, mild or moderate COVID-19 did not reduce disease progression to severe COVID-19.
Trial Registration Number: Sri Lanka Clinical Trials Registry; SLCTR/2021/017.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729268 | PMC |
| http://dx.doi.org/10.1136/bmjopen-2023-075803 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
From Pandemic to COVID-19 Endemic: Mental Health Impact, Psychological and Social Well-Being Among Social Work Students-Implications for the Healthcare System.
Healthcare (Basel)
December 2024
Department of Sociology, Social Work and Human Resources, "Alexandru Ioan Cuza" University of Iași, 700506 Iaşi, Romania.
Our research paper aims to analyse the relationship between the perceived impact on mental health due to the COVID-19 pandemic, social well-being, and psychological well-being among social work students. As we transition from the pandemic phase to an endemic phase of COVID-19, it is necessary to examine these aspects, recognizing the interdependence and complementarity of social and medical care within the healthcare system. The research was conducted nearly three years after the lockdown measures imposed by the spread of COVID-19, during a period when onsite academic activities had resumed, as they were prior to the pandemic.
View Article and Find Full Text PDFEffects of pandemic on families, parenting stress, and emotional well-being of children in villages under Mugalur Subcentre, Sarjapur PHC, Bengaluru.
J Family Med Prim Care
December 2024
Interns, Department of Community Medicine, St Johns Medical College, Bengaluru, Karnataka, India.
Introduction: The COVID-19 pandemic has not only affected the health status of the population but has also had a serious impact on family dynamics, especially in the relationship between parents and children. Home confinement along with the closures of schools has had a strong negative impact on the psychosocial wellbeing of children. This study assesses the effects of the pandemic on families, parenting stress, and emotional well-being of children in villages under Mugalur Sub-centre, Sarjapur PHC, Bengaluru.
View Article and Find Full Text PDFPrevalence and control of hypertension in COVID-19 positive cases.
J Family Med Prim Care
December 2024
Health Education and Promotion, Faculty of Public Health and Health Informatics, Umm Al-Qura University, Alziziah Makkah, Saudi Arabia.
Background: The coronavirus disease (COVID-19) is an infectious disease caused by the newly discovered SARS-CoV-2 virus. Patients diagnosed with COVID-19 experience several complications including hypertension or elevated blood pressure which is a serious medical condition that significantly increases the risks of heart, brain, and kidney diseases.
Objectives: To assess the prevalence and control of hypertension in COVID-19 patients.
Evaluation of the long-term effects of COVID-19 on pulmonary functions in recovered patients.
J Family Med Prim Care
December 2024
Vice Chancellor, Atal Bihari Vajpayee Medical University, Lucknow, Uttar Pradesh, India.
Background: It is documented that COVID-19 survivors have prolonged morbidity and functional impairment for many years. Data regarding post-COVID-19 lung functions is lacking from the Indian population. We aim to evaluate the lung functions in such patients after 3-6 months of hospital discharge.
View Article and Find Full Text PDFUnequal Effects of the Lockdown on Mental Health in Shanghai: The Moderating and Mediating Role of Neighborhood Environment and Online Social Connections.
J Community Psychol
January 2025
Rory Meyers College of Nursing, New York University, New York, New York, USA.
The COVID-19 pandemic profoundly impacted population mental health worldwide. Few studies examined how the neighborhood environment and online social connections might influence the social gradient in mental health during the pandemic lockdown. We aim to examine the moderating and mediating role of neighborhood environment and online social connections in the association between socioeconomic status (SES) and mental health outcomes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!