AI Article Synopsis
- The study examines how amide proton transfer weighted (APTw) imaging combined with diffusion kurtosis imaging (DKI) can help predict lymph node metastasis (LNM) in cervical carcinoma patients.
- Data from 69 patients (19 with LNM and 50 without) were analyzed using a 3.0 T MRI scan, and significant differences in MTRasym and mean kurtosis values were found between the two groups, indicating potential predictive value.
- The findings suggest that APTw and DKI could serve as valuable tools in the clinical evaluation of cervical carcinoma, improving diagnosis and treatment strategies for LNM.
Article Abstract
Objective: To investigate the value of amide proton transfer weighted (APTw) combined with diffusion kurtosis imaging (DKI) in quantitative prediction of lymph node metastasis (LNM) in cervical carcinoma (CC).
Methods: Data of 19 LNM(+) and 50 LNM(-) patients with CC were retrospectively analyzed. 3.0 T MRI scan was performed before the operation, including APTw and DKI. After post-processing, quantitative magnetization transfer ratio asymmetric at 3.5 ppm [MTRasym (3.5 ppm)], mean kurtosis (MK), and mean diffusivity (MD) maps were obtained. The MTRasym(3.5 ppm), MK, and MD values were respectively measured by two observers, and intra-class correlation coefficients (ICC) were used to test the consistency of the results. The independent samples t-test or Mann-Whitney U test was used to compare the differences in the values of each parameter. The ROC curve was used to analyze the predictive performance of parameters with significant differences and their combination parameter.
Results: The two observers had good agreement in the measurement of each data (ICC > 0.75). The MTRasym(3.5 ppm) and MK values of the LNM(+) group(3.260 ± 0.538% and 0.531 ± 0.202) were higher than those of the LNM(-) group(2.698 ± 0.597% and 0.401 ± 0.148) (P < 0.05), while there was no significant difference in MD values between the two groups(P > 0.05). The area under the curves (AUCs) of MTRasym(3.5 ppm), MK value, and MTRasym(3.5 ppm) + MK value were 0.763, 0.716, and 0.813, respectively, when predicting LNM status of CC.
Conclusion: APTw and DKI can quantitatively predict LNM status of CC, which is of importance in clinical diagnosis and treatment.
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| http://dx.doi.org/10.1016/j.mri.2023.12.001 | DOI Listing |
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