Electrochemical oxidative dehydrogenative annulation of 1-(2-aminophenyl)pyrroles with cleavage of ethers to synthesize pyrrolo[1,2-]quinoxaline derivatives.

Org Biomol Chem

College of Pharmacy, Ningxia Characteristic Traditional Chinese Medicine Modern Engineering Research Center, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.

Published: January 2024

AI Article Synopsis

  • - An array of pyrrolo[1,2-]quinoxaline derivatives was successfully created through an electrochemical redox reaction with varying yields.
  • - This reaction involved the functionalization of C(sp)-H bonds and the formation of both C-C and C-N bonds.
  • - THF served as both a reactant and a solvent in this atom-economical process, resulting in hydrogen (H) as the only by-product.

Article Abstract

An array of pyrrolo[1,2-]quinoxaline derivatives were achieved with moderate to good yields the electrochemical redox reaction, which includes the functionalization of C(sp)-H bonds and the construction of C-C and C-N bonds. In this atom economic reaction, THF was used as both a reactant and a solvent, and H was the sole by-product.

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http://dx.doi.org/10.1039/d3ob01867aDOI Listing

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