An array of pyrrolo[1,2-]quinoxaline derivatives were achieved with moderate to good yields the electrochemical redox reaction, which includes the functionalization of C(sp)-H bonds and the construction of C-C and C-N bonds. In this atom economic reaction, THF was used as both a reactant and a solvent, and H was the sole by-product.
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http://dx.doi.org/10.1039/d3ob01867a | DOI Listing |
Molecules
April 2021
Heterocyclic Unit, National Research Centre, Photochemistry Department, Dokki, Giza 12622, Egypt.
In this article, we showed the synthesis of new polycyclic aromatic compounds, such as thienotriazolopyrimidinones, -(thienotriazolopyrimidine) acetamide, 2-mercapto-thienotriazolo-pyrimidinones, 2-(((thieno-triazolopyrimidine) methyl) thio) thieno-triazolopyrimidines, thieno-pyrimidotriazolo-thiazines, pyrrolo-triazolo-thienopyrimidines, thienopyrimido-triazolopyrrolo-quinoxalines, thienopyrimido-triazolo-pyrrolo-oxathiino-quinoxalinones, 1,4-oxathiino-pyrrolo- triazolothienopyrimidinones, imidazopyrrolotriazolothienopyrimidines and 1,2,4-triazoloimidazo- pyrrolotriazolothienopyrimidindiones, based on the starting material 2,3-diamino-6-benzoyl-5- methylthieno[2,3-d]pyrimidin-4(3)-one (). The chemical structures were confirmed using many spectroscopic ways (IR, H, C, -NMR and MS) and elemental analyses. A series of thiazine, imidazole, pyrrole, thienotriazolopyrimidine derivatives were synthesized and evaluated for their antiproliferative activity against four human cancer cell lines, i.
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