Association of the cytochrome P450 and arylamine N-acetyltransferase gene polymorphisms with the incidence of head and neck cancer in Polish population.

Objectives: Head and neck cancer (HNC) is one of the most common cancers. Most exogenous HNC is head and neck squamous cell carcinomas. Scientists are striving to develop diagnostic tests that will allow the prognosis of HNC. The aim of the study was to determine the risk of HNC. The research concerned changes caused by polymorphisms in genes encoding proteins responsible for the metabolism of xenobiotics.

Material And Methods: In group of 280 patients with HNC, the occurrence of polymorphic variants in (rs72554606), (rs1799930), (rs1799814), (rs3892097) were studied with TaqMan technique. The control group consisted of 260 cancer free people. The TNM scale was analyzed. Gene interactions of genotyped polymorphisms were investigated. The effects of smoking and alcohol consumption on HNC were assessed.

Results: The results indicated an increased risk of HNC in polymorphisms in the genotype (OR = 1.772, 95% CI: 1.184-2.651, p = 0.005) and polymorphism in the genotype (OR = 1.506, 95% CI: 1.023-2.216, p = 0.037). The protective phenomenon in the polymorphism the genotype (OR = 0.587, 95% CI: 0.381-0.903, p = 0.015) and the genotype (OR = 0.268, 95% CI: 0.159-0.452, p = 0.001). The coexistence of polymorphisms (OR = 2.687, 95% CI: 1.387-5.205, p = 0.003) in genes increases the risk of HNC. Risk-reducing effect in the polymorphism (OR = 0.340, 95% CI: 0.149-0.800, p = 0.011), (OR = 0.077, 95% CI: 0.028-0.215, p < 0.0001), (OR = 0.250, 95% CI: 0.100-0.622, p = 0.002), (OR = 0.276, 95% CI: 0.112-0.676, p = 0.002) in genes. In the genes in the polymorphisms (OR = 0.338, 95% CI: 0.132-0.870, p = 0.020), (OR = 0.100, 95% CI: 0.027-0.359, p = 0.001), (OR = 0.190, 95% CI: 0.072-0.502, p = 0.0004), (OR = 0.305, 95% CI: 0.107-0.868, p = 0.024). Correlation was noted between cigarette smoking and HNC (OR = 7.297, 95% CI: 4.989-10.674, p < 0.0001) and consuming alcohol (OR = 1.572, 95% CI: 1.003-2.464, p = 0.047).

Conclusions: The polymorphism shows a protective association with HNC. On the other hand, , polymorphism influence the susceptibility to developing HNC. The coexistence of the genotypes increases the risk of HNC. In contrast, and reduce this risk. Smoking and alcohol consumption increase the incidence of HNC. Int J Occup Med Environ Health. 2023;36(6):812-24.