AI Article Synopsis
- Infections pose a significant threat to health, making rapid detection of harmful bacteria vital for effective treatment.
- Researchers developed a novel biosensor using pomegranate seed-structured bimetallic gold-platinum nanomaterials (Ps-PtAu NPs) that can quickly change the color of a substrate for easier detection of bacteria.
- The biosensor can accurately detect bacterial levels as low as 3.9 CFU/mL and allows for on-site testing using a smartphone app, demonstrating high sensitivity and specificity in clinical applications.
Article Abstract
() infections are a serious threat to human health. The development of rapid and sensitive detection methods for pathogenic bacteria is crucial for accurate drug administration. In this research, by combining the advantages of enzyme-linked immunosorbent assay (ELISA), we synthesized nanozymes with high catalytic performance, namely pomegranate seed-structured bimetallic gold-platinum nanomaterials (Ps-PtAu NPs), which can catalyze a colorless TMB substrate into oxidized TMB (oxTMB) with blue color to achieve colorimetric analysis of . Under the optimal conditions, the proposed biosensor could quantitatively detect at levels ranging from 1.0 × 10 to 1.0 × 10 CFU mL with a limit of detection (LOD) of 3.9 CFU mL. Then, an integrated color picker APP on a smartphone enables on-site point-of-care testing (POCT) of with LOD as low as 1 CFU mL. Meanwhile, the proposed biosensor is successfully applied to the detection of in clinical samples with high sensitivity and specificity.
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| http://dx.doi.org/10.1039/d3an01621h | DOI Listing |
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