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Influence of electrolyte imbalance on regional wall motion abnormalities in STEMI patients of North Indian origin. | LitMetric

Influence of electrolyte imbalance on regional wall motion abnormalities in STEMI patients of North Indian origin.

Front Cardiovasc Med

Cardiac Aging & Redox Signaling Laboratory, Molecular and Cellular Pathology, Department of Pathology, Birmingham, AL, United States.

Published: November 2023

AI Article Synopsis

  • Assessing regional wall motion abnormalities (RWMA) in the myocardium helps diagnose and manage chronic remodeling in patients with ST-segment elevation myocardial infarction (STEMI), particularly those with anterior STEMI.
  • In a study with 217 subjects, RWMA was found not only in the left anterior descending (LAD) territory but also in various regions, indicating a broader dysfunction.
  • Significant correlations were observed between serum electrolyte levels (sodium, potassium) and the presence of RWMA, suggesting that monitoring and correcting these imbalances may enhance treatment outcomes.

Article Abstract

Assessing regional wall motion abnormalities (RWMA) in the myocardium may provide early diagnosis and treat chronic remodeling in STEMI patients. We assessed RWMA in 217 subjects with anterior STEMI admitted to Era University Hospital in Lucknow, UP, India. Besides abnormalities in the LAD territory, sub-sets of patients exhibited diffuse regional myocardial dysfunction. Interestingly, variations in serum electrolytes, specifically sodium and potassium, significantly affected the distribution and frequency of RWMA. Notably, RWMA occurred in the basal septum, apical septum, apex, and lateral wall in the anterior STEMI group. Additionally, the rate of regional dysfunction varied with serum urea and creatinine levels. This suggests that anterior STEMI can manifest myocardial abnormalities beyond the LAD territory. These findings indicate that ST-segment elevation might not be specific, possibly influenced by electrolyte changes affecting cardiac rhythm. Therefore, diagnosing and correcting region-specific wall motion abnormalities and electrolyte imbalances may improve outcomes in STEMI patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10720728PMC
http://dx.doi.org/10.3389/fcvm.2023.1223954DOI Listing

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