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Bilateral Involvement in Childhood Presumed Trematode Induced Granulomatous Anterior Uveitis.
Ocul Immunol Inflamm
November 2024
Ophthalmology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Purpose: This study aims to elucidate the clinical spectrum of trematode-induced uveitis (TIU), with a particular focus on its bilateral presentation and providing significant insights into its pathophysiology.
Methods: A prospective cross-sectional observational study was conducted at the uveitis outpatient clinic of Mansoura University Ophthalmic Center. The study involved children diagnosed with presumed TIU.
Familial Subcutaneous Granuloma Annulare: A Case Report of Two Siblings.
Cureus
October 2024
Department of Dermatology, Cliniques universitaires Saint-Luc (UCLouvain), Brussels, BEL.
Granuloma annulare (GA) is a rare inflammatory granulomatous disorder and its subcutaneous forms are even more uncommon. Only a few familial cases of this condition have been reported in the literature. We report a case of familial subcutaneous GA in two siblings during childhood.
View Article and Find Full Text PDFVariable clinical presentation of hypomorphic DCLRE1C deficiency from childhood to adulthood.
Pediatr Allergy Immunol
October 2024
Division of Pediatric Immunology and Allergy, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Article Synopsis
- The study focuses on long-term follow-up of 18 pediatric and adult patients with hypomorphic DCLRE1C mutations diagnosed with leaky severe combined immunodeficiency (SCID).
- Common clinical manifestations included recurrent infections, skin issues, autoimmune diseases, and malignancy, with a significant number of patients showing low immunoglobulin levels and T/B-cell lymphopenia.
- Findings suggested a dominant Th1 immune response, with elevated IFN-γ and T cells contributing to chronic inflammation and autoimmunity, emphasizing the need for ongoing patient monitoring post-hematopoietic stem cell transplantation (HSCT).
Management of JIA associated uveitis.
Best Pract Res Clin Rheumatol
September 2024
Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, UK; Translational Health Science, University of Bristol, Bristol, UK. Electronic address:
Article Synopsis
- Juvenile Idiopathic Arthritis (JIA) is a common chronic childhood condition that can lead to uveitis in 20-25% of cases, requiring regular screening for early detection.
- Uveitis is typically chronic, asymptomatic, and involves inflammation in the front part of the eye, making collaboration between paediatric rheumatologists and ophthalmologists essential for effective management.
- Treatment usually begins with methotrexate, and if ineffective, may progress to adalimumab, with alternative options like anti-IL6 and anti-TNF agents available for persistent cases, though evidence for these is limited.
Blaschkoid granulomatous pigmented purpuric dermatosis in childhood.
J Dermatol
January 2025
Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
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