AI Article Synopsis
- Lysine-specific demethylase 1A (LSD1) interacts with REST corepressor (RCOR) proteins to modify histones, influencing transcription regulation based on the specific RCOR present in the complex.
- The study reveals that RCOR genes originated from two rounds of whole-genome duplications in early vertebrate evolution, while LSD genes date back to before the split between animals and plants.
- By using bioinformatics, researchers traced the evolution of the LSD1-RCOR complex and suggested that studying non-model animal species could enhance our understanding of this epigenetic interaction.
Article Abstract
Lysine-specific demethylase 1A (LSD1) binds to the REST corepressor (RCOR) protein family of corepressors to erase transcriptionally active marks on histones. Functional diversity in these complexes depends on the type of RCOR included, which modulates the catalytic activity of the complex. Here, we studied the duplicative history of the RCOR and LSD gene families and analyzed the evolution of their interaction. We found that RCOR genes are the product of the two rounds of whole-genome duplications that occurred early in vertebrate evolution. In contrast, the origin of the LSD genes traces back before to the divergence of animals and plants. Using bioinformatics tools, we show that the RCOR and LSD1 interaction precedes the RCOR repertoire expansion that occurred in the last common ancestor of jawed vertebrates. Overall, we trace LSD1-RCOR complex evolution and propose that animal non-model species offer advantages in addressing questions about the molecular biology of this epigenetic complex.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10721905 | PMC |
| http://dx.doi.org/10.1038/s42003-023-05652-x | DOI Listing |
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