In order to reveal whether thyrotroph cells of the human pituitary are affected by aging, a histologic and immunocytologic study was undertaken on the pituitaries of patients over 80 years of age (10 men, 10 women), dying of various acute illnesses and the findings compared with those of a younger age group (10 men, 10 women), dying of various acute illnesses between the age of 20-56 years. The incidence, distribution, granulation, cytoplasmic vacuolization, as well as immunoreactivity of TSH cells, showed no major differences related to age and sex. Lack of involution of thyrotroph cells in old subjects indicates that the pituitary is capable of producing TSH with advancing age.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Permanent cilia loss during cerebellar granule cell neurogenesis involves withdrawal of cilia maintenance and centriole capping.
Proc Natl Acad Sci U S A
December 2024
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Brain neurons utilize the primary cilium as a privileged compartment to detect and respond to extracellular ligands such as Sonic hedgehog (SHH). However, cilia in cerebellar granule cell (GC) neurons disassemble during differentiation through ultrastructurally unique intermediates, a process we refer to as cilia deconstruction. In addition, mature neurons do not reciliate despite having docked centrioles.
View Article and Find Full Text PDFAutomated Quantification of Meiotic Recombination Foci Position and Intensity.
Methods Mol Biol
August 2024
Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, UK.
During meiosis, homologous chromosomes reciprocally exchange segments of DNA via the formation of crossovers. However, the frequency and position of crossover events along chromosomes are not random. Each chromosome must receive at least one crossover, and the formation of a crossover at one location inhibits the formation of additional crossovers nearby.
View Article and Find Full Text PDFDiagnostic Significance of Cytokeratin 20 and p53 as Adjunct Immunocytological Markers in Urine Cytology to Detect Urothelial Carcinomas: A Systematic Review Study.
Iran J Pathol
July 2023
Department of Pathology, Sree Mookambika Institute of Medical Sciences, Kulasekharam. The Tamilnadu Dr. M.G.R Medical University, India.
The progression and recurrence of urothelial carcinoma (UC) are correlated with carcinoma and urothelial dysplasia. It is frequently challenging to distinguish dysplasia and carcinoma from reactive atypia only based on histological characteristics. In daily practices, 2 of the adjunct immunohistochemistry markers (cytokeratin 20 (CK20) and p53) are used in addition to the histology to diagnose carcinoma .
View Article and Find Full Text PDFEvaluating the Feasibility of Hydrogel-Based Neural Cell Sprays.
J Funct Biomater
October 2023
Neural Tissue Engineering, School of Life Sciences, Keele University, Staffordshire ST5 5BG, UK.
Neurological injuries have poor prognoses with serious clinical sequelae. Stem cell transplantation enhances neural repair but is hampered by low graft survival (
Telomere-Associated Changes in Nuclear Architecture of Cancer-Associated Macrophage-like Cells in Liquid Biopsies from Melanoma Patients.
Biomedicines
September 2022
CancerCare Manitoba Research Institute, University of Manitoba, Winnipeg, MB R3C 2B1, Canada.
During phagocytosis, tumor-associated macrophages (TAMs) can incorporate genetic material from tumor cells. The incorporation of extra genetic material may be responsible for advanced malignant behavior observed in some TAMs, making TAMs potentially important players in cancer progression. More recently, similar cells were described in the blood as cancer-associated macrophage-like cells (CAMLs).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!