Full-face ALA-PDT for facial actinic keratosis: Two case reports.

Photodiagnosis Photodyn Ther

Department of Dermatology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, PR China. Electronic address:

Published: February 2024

AI Article Synopsis

  • Two cases of full-face 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) were reported for treating multiple actinic keratosis (AK) on the face.
  • After treatment, all AK lesions were completely cleared, and the patients experienced facial rejuvenation.
  • Follow-up showed one patient remained lesion-free for over 13 months, while the other was free for over 28 months, suggesting ALA-PDT may be highly effective in treating AK and preventing recurrence.

Article Abstract

We reported two cases of full-face 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) for facial multiple actinic keratosis (AK). After the full-face ALA-PDT, we observed that the AK lesions on the faces of the patients were completely cleared and facial rejuvenation was achieved. In our follow-up, one patient was free of recurrence for over 13 months and the other one for over 28 months. The experience of these two cases may indicate that full-face ALA-PDT has an excellent therapeutic effect while potentially preventing the recurrence of AK.

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http://dx.doi.org/10.1016/j.pdpdt.2023.103927DOI Listing

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Full-face ALA-PDT for facial actinic keratosis: Two case reports.

Photodiagnosis Photodyn Ther

February 2024

Department of Dermatology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, PR China. Electronic address:

Article Synopsis
  • Two cases of full-face 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) were reported for treating multiple actinic keratosis (AK) on the face.
  • After treatment, all AK lesions were completely cleared, and the patients experienced facial rejuvenation.
  • Follow-up showed one patient remained lesion-free for over 13 months, while the other was free for over 28 months, suggesting ALA-PDT may be highly effective in treating AK and preventing recurrence.
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Topical aminolevulinic acid (ALA) photodynamic therapy (PDT) is currently being used for the treatment of actinic keratosis of the face and scalp. This study reports the results obtained after three to four treatments with ALA-PDT in patients with acne (n=12), photoaging (n=8) and vitiligo (n=6). ALA was applied on large areas (e.

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Background: Photodynamic therapy (PDT) with a 5-aminolevulinic acid (ALA) photosensitizing agent and a variety of lasers and light sources has been shown to enhance the treatment of photodamaged skin and its associated actinic keratoses (AKs). The efficacy of short-contact, full-face ALA by PDT in photorejuvenation has also been demonstrated.

Objective: To evaluate short-contact (30 to 60 min) ALA-PDT with intense pulsed light (IPL) activation by comparing ALA-PDT-IPL with IPL alone.

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