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Alterations in the gut microbiome and metabolism with doxorubicin-induced heart failure severity.
Front Microbiol
December 2024
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Objective: This study aimed to explore the changes in gut microbiota and its metabolites in different pathophysiological stages of doxorubicin (DOX)-induced heart failure (DIHF) and the relationship between gut microbiota and metabolites in various degrees of DIHF.
Materials And Methods: C57BL/6 J mice were injected intraperitoneally with 5 mg/kg of DOX once a week for 5 consecutive weeks. At different times after injection, the cardiac function and histopathological analysis was conducted, the serum levels of creatine kinase (CK), CK-MB, lactic dehydrogenase, and cardiac troponin T were determined.
High Anion Gap Metabolic Acidosis and 5-Oxoprolinuria in a Hospital Setting Induced by Acetaminophen, Sepsis, and Malnutrition: A Case Report.
Cureus
December 2024
Nephrology, NewYork-Presbyterian Queens, New York, USA.
High anion gap metabolic acidosis (HAGMA) is a common biochemical abnormality in hospitalized patients, often linked to conditions such as lactic acidosis, renal failure, or drug toxicity. A rare etiology, 5-oxoprolinuria, resulting from acetaminophen use, malnutrition, and sepsis, is increasingly recognized in critically ill patients. We report a 29-year-old male with a history of intellectual disability and normal baseline kidney function who was admitted with acute necrotizing pancreatitis and developed severe metabolic acidosis and acute kidney injury (AKI).
View Article and Find Full Text PDFAfter Bypass Cardiac Surgery, Over 50% of the Patients Developed a Severe Lactic Acidosis While Having Normal Hemodynamics: We Would Like to Put Forward an Hypothesis!
Crit Care Med
January 2025
Gynecology Department, Université Libre de Bruxelles, Brussels, Belgium.
Clinical efficacy and hemodynamic effects of levosimendan in cardiac surgery patients after surgery.
J Cardiothorac Surg
January 2025
Department of Anesthesiology, Zibo Central Hospital, No.10 Shanghai Road, Zhangdian District, Zibo City, 255000, Shandong Province, China.
Objective: To investigate the therapeutic effect of levosimendan on hemodynamics in patients undergoing major cardiac surgery and presenting with acute postoperative heart failure.
Methods: The subjects of the study were 160 patients with severe cardiac conditions who underwent surgery and had acute heart failure. Eighty cases each were assigned to the research and control groups using a random number table.
Effect of acetate- and lactate-containing intravenous fluid on acid-base status, electrolytes and plasma lactate concentration in dehydrated cats.
J Feline Med Surg
January 2025
LMU Small Animal Clinic, Center for Clinical Veterinary Medicine, LMU Munich, Munich, Germany.
Objectives: Acetate (ACE) and lactate (LAC)-containing balanced resuscitation fluids are commonly used for fluid therapy in cats. These fluids can influence acid-base and electrolyte status. This prospective randomised study compared two balanced crystalloid solutions regarding their effect on acid-base status, electrolytes and LAC concentrations in dehydrated cats after intravenous fluid therapy.
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