Introduction: Carcinoma arising from the axillary tail of Spence (CATS) is a rare entity that requires a high level of clinical suspicion. The clinicopathologic, prognostic, and imaging features of CATS are poorly understood.
Case Summary: A 46-year-old woman presented to our hospital with right axillary swelling associated with bleeding and foul-smelling discharge. She had initially presented to a different hospital with a similar presentation where she was diagnosed with metastatic carcinoma, favouring adenocarcinoma on the FNAC report, following which she received 3 cycles of chemotherapy. MRI and PET-CT scan workups at our hospital showed a soft tissue mass likely arising from the axillary tail of the right breast with a few enlarged axillary lymph nodes and an unremarkable right breast. She underwent excision of the mass with axillary lymph node dissection and reconstruction with a pedicled Latissimus dorsi flap. The final diagnosis was based on immunohistochemistry, with tumor cells positive for GATA3 and CK-7, negative for estrogen and progesterone receptors (ER, PR), positive for human epidermal growth factor receptor 2 (Her2 neu), and having a Ki-67 labelling index of 45 %.
Discussion: Carcinoma of the axillary tail of Spence (CATS) has a reported incidence of 0.3 %. There have been only few papers till date that have reported the clinicopathologic, prognostic, and imaging features of CATS. MRI is an important imaging modality to localize CATS. Histologic examination aids in the diagnosis by identifying the presence of a histologic pattern of primary breast carcinoma and immunohistochemical characteristics such as ER, PR, Her2neu, and gross cystic disease fluid protein (GCDFP). Due to the rarity of CATS, no specific guidelines concerning management currently exist. Surgical management involves wide local excision of the axillary mass with axillary lymph node dissection.
Conclusion: CATS, even though rare, should be considered in the differential diagnosis of a patient presenting with an axillary mass. MRI is a valuable tool to distinguish CATS from other lesions. Immunohistochemistry is essential to confirm the diagnosis.
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http://dx.doi.org/10.1016/j.ijscr.2023.109151 | DOI Listing |
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January 2025
Gynecology Department, Coimbra University Hospital Center, Coimbra, Portugal.
Establishing an accurate prognosis for women diagnosed with breast cancer (BC) is extremely challenging. Axillary lymph node (ALN) evaluation is considered of major prognostic value. The one-step nucleic acid amplification (OSNA) assay is currently used for assessing axillary sentinel lymph node (SLN) status in BC.
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Department of Plastic and Hand Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne (UNIL), Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Introduction: In microvascular breast reconstruction, the focus has shifted to achieving aesthetically pleasing results. Delayed breast reconstruction poses challenges such as ensuring natural ptosis and avoiding a "patch" effect. The Be.
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Magnetic Insight Inc., Alameda, CA 94502, United States.
Background: Sentinel lymph node biopsy (SLNB) is an important cancer diagnostic staging procedure. Conventional SLNB procedures with Tc radiotracers and scintigraphy are constrained by tracer half-life and, in some cases, insufficient image resolution. Here, we explore an alternative magnetic (nonradioactive) image-guided SLNB procedure.
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Department of Radiology, University of Miami Miller School of Medicine, Sylvester Cancer Center, and Jackson Memorial Hospital, Florida, USA.
We present the case of a forty-year-old asymptomatic female with no personal or family history of breast cancer, who underwent a core needle biopsy (CNB) following the identification of a focal asymmetry in the right breast on screening mammography. Eight months later, a prominent adjacent vascular structure with a round outpouching was detected on breast ultrasound, confirmed as a post-biopsy pseudoaneurysm. Breast pseudoaneurysms, although exceedingly rare, result from inadvertent vessel puncture during core needle biopsies, particularly when larger gauge needles are used.
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August 2024
College of Traditional Chinese Medicine, Changchun University of Chinese Medicine;
Membranous nephropathy (MN) is a common pathological type of adult nephrotic syndrome. Up to 20% of patients with MN develop end-stage renal disease (ESRD). Podocytes have an important function in maintaining the glomerular filtration barrier and play a crucial role in the occurrence and development of proteinuria and MN.
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