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http://dx.doi.org/10.1200/PO.23.00287 | DOI Listing |
JCO Precis Oncol
September 2023
Department of Internal Medicine, Division of Hematology/Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Cancer Res Commun
May 2022
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Anaplastic lymphoma kinase (ALK) is a tyrosine kinase with genomic and expression changes in many solid tumors. ALK inhibition is first line therapy for lung cancers with alterations, and an effective therapy in other tumor types, but has not been well-studied in prostate cancer. Here, we aim to delineate the role of ALK genomic and expression changes in primary and metastatic prostate cancer.
View Article and Find Full Text PDFCancers (Basel)
March 2021
Division of Medical Oncology, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI 48109-5848, USA.
Rearrangements in the Anaplastic Lymphoma Kinase () gene have been implicated in 5-6% of all non-small cell lung cancers. -rearranged non-small cell lung cancers are sensitive to -directed tyrosine kinase inhibitors, but generally resistant to single-agent immune checkpoint inhibitors. Here, we aim to describe the mechanisms of aberrations in non-small cell lung cancer by which an immunosuppressed tumor microenvironment is created, leading to host immune evasion.
View Article and Find Full Text PDFJCO Precis Oncol
January 2018
Department of Medicine, Massachusetts General Hospital, Boston, MA.
Purpose: rearrangements predict for sensitivity to ALK tyrosine kinase inhibitors (TKIs). However, responses to ALK TKIs are generally short-lived. Serial molecular analysis is an informative strategy for identifying genetic mediators of resistance.
View Article and Find Full Text PDFClin Cancer Res
November 2014
Medicine (Section of Medical Oncology), Yale University School of Medicine and Yale Cancer Center, New Haven, Connecticut.
Mutations in ALK are a common mechanism of acquired resistance to small molecule ALK inhibitors in ALK-rearranged lung cancer. Different mutants exhibit differential sensitivity to ALK inhibitors. Matching the mutational profile of the tumor with the appropriate ALK inhibitor is likely to be important to maximize benefit for patients.
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