AI Article Synopsis
- Checkpoint inhibitor colitis is often underestimated and leads to few hospital admissions despite its frequency, requiring a thorough history and endoscopic assessment for severe cases.
- The fecal calprotectin test can aid in diagnosis, and treatment options are generally effective, with second-line therapies being infrequently used.
- Recent findings suggest that severe cases should receive biological therapies promptly to reduce infection risk from corticosteroids, as the study aims to assess the effectiveness of various therapies for immunotherapy-related colitis at CHU of Liège.
Article Abstract
Checkpoint inhibitor colitis is a complication that is often underestimated when it is slow-grade, and results in relatively few hospital admissions compared to its frequency of occurrence. A strict history-taking approach, combined with an endoscopic work-up in cases of severity, is recommended. The use of the fecal calprotectin may also be useful. When used appropriately, the various lines of treatment are generally effective, and second-line therapies (biotherapies) are rarely used. However, recent evidence suggests that patients with severe symptoms should be treated more rapidly with biological therapies, especially if severity is endoscopically confirmed, as corticosteroids carry a greater risk of infection. The objective of this study is to demonstrate the efficacy of non-symptomatic, first and second line therapies for immunotherapy-related colitis in a population of patients at the CHU of Liège.
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