Antibacterial activity of soil-isolated complex against methicillin-resistant from Mwanza, Tanzania.

Unlabelled: Antimicrobial resistance in methicillin-resistant and beta-lactamase-producing Gram-negative bacteria is a global health concern necessitating research and the development of effective antimicrobial agents. This study, conducted in May 2020 in Mwanza, Tanzania, aimed to determine the antibacterial activity of metabolites from soil-isolated species against clinical bacterial pathogens. One soil-isolated species, identified as complex, showed antibacterial activity against Gram-positive cocci, including a methicillin-resistant strain with inducible clindamycin resistance, previously isolated from a patient with osteomyelitis. complex metabolites may be a potential source of antimicrobial agents against multidrug-resistant bacteria.

What This Study Adds: The study supports existing research on the discovery and development of new antimicrobial agents against multi-drug-resistant bacteria. We report the antimicrobial activity of metabolites extracted from soil-isolated complex strains against Gram-positive bacteria, including a methicillin-resistant strain with inducible clindamycin resistance.