A selective [4 + 2] cycloaddition reaction of thiazolo-2-pyridones with arynes has been demonstrated. The developed protocol allows rapid access to highly functionalized, structurally complex thiazolo-fused bridged isoquinolones in high yields, which are susceptible to further late-stage functionalization.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10777404PMC
http://dx.doi.org/10.1021/acs.joc.3c01957DOI Listing

Publication Analysis

Top Keywords

selective cycloaddition
8
synthesis three-dimensional
4
three-dimensional ring
4
ring fused
4
fused heterocycles
4
heterocycles selective
4
cycloaddition bicyclic
4
bicyclic thiazolo
4
thiazolo 2-pyridones
4
2-pyridones arynes
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!