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Interferon-gamma release assay for screening of tuberculosis infection in children. | LitMetric

Interferon-gamma release assay for screening of tuberculosis infection in children.

BMC Infect Dis

Laboratory of Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Children's Hospital, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Beijing Pediatric Research Institute, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Published: December 2023

AI Article Synopsis

  • - The study compared two tests, QuantiFERON-TB Gold In-Tube (QFT-GIT) and X.DOT-TB (XDOT), for diagnosing latent tuberculosis infection (LTBI) in children under 18, finding that indeterminate results occurred more frequently in younger patients, especially those with respiratory diseases.
  • - A total of 33,662 children were tested, revealing that X.DOT had a higher positive rate (3.1%) compared to QFT-GIT (1.8%) and that the rate of indeterminate results decreased with age.
  • - Factors like being male, younger age, and having certain underlying diseases were significantly linked to a higher risk of indeterminate IGRA results,

Article Abstract

Background: Interferon-gamma release assay (IGRA) is the main tool for the diagnosis of latent tuberculosis (TB) infection (LTBI). However, the indeterminate results were more frequent in children, and the underlying reasons were largely speculative. We aimed to compare QuantiFERON-TB Gold In-Tube (QFT-GIT) with X.DOT-TB (XDOT) for diagnosing LTBI, and to identify the risk factors associated with indeterminate results in children.

Methods: A retrospective study for children<18 years old, at risk for LTBI or progression to TB disease, received either QFT-GIT or X.DOT-TB tests was performed at Beijing Children's Hospital from August 2019 to August 2022.

Results: A total of 33,662 children were recruited, including 15,129 (44.9%) tested with X.DOT-TB and 18,533 (55.1%) with QFT-GIT. Proportion of positive and indeterminate results in children with respiratory disease was significantly higher than did that with other diseases, respectively (P < 0.001). The indeterminate rate of X.DOT-TB and QFT-GIT results decreased with increasing age (P < 0.001). Proportion of QFT-GIT indeterminate results was higher than that of X.DOT-TB across age groups. Male, age and disease classification all presented a statistically significant association with indeterminate IGRA results.

Conclusions: The positive rates of X.DOT-TB and QFT-GIT in children were 3.1% and 1.8%, respectively. The X.DOT-TB assay performed better than QFT-GIT in children, and male, age and underlying diseases were associated with an increased risk of indeterminate IGRA results.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717111PMC
http://dx.doi.org/10.1186/s12879-023-08871-zDOI Listing

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