AI Article Synopsis
- The study aimed to measure neutralizing SARS-CoV-2 antibodies in maternal serum, cord blood, and breast milk after vaccination and infection to see how they relate to spike protein binding antibodies.
- It involved 100 women who gave birth, assessing their antibody levels to determine the impact of previous infection and vaccination on maternal and infant immunity.
- Results showed that maternal neutralizing antibody levels increased after both vaccination and infection, but decreased quickly; these antibodies were also found in higher concentrations in cord blood than in maternal blood, and spike protein binding antibodies closely related to neutralizing antibody levels.
Article Abstract
Objective: We quantified neutralizing SARS-CoV-2 antibody against spike protein (nAb) levels after vaccination and SARS-CoV-2 infection in maternal serum, cord blood, and breast milk and determined whether they correlate with levels of spike protein binding antibody.
Study Design: Women (n = 100) were enrolled on admission for delivery. Previous SARS-CoV-2 infection was defined by anti-nucleocapsid antibodies. Levels of nAb and binding antibodies against spike receptor binding domain were measured in maternal blood, cord blood, and milk.
Results: Maternal nAb levels were higher after vaccine and infection than vaccine alone but waned rapidly. Levels of nAb in cord blood and milk correlated with maternal levels and were higher in cord blood than maternal. Spike protein binding antibody levels correlated with nAb.
Conclusion: SARS-CoV-2 vaccination near delivery may boost antibody-mediated immunity in the peripartum period. Neutralizing antibodies are passed transplacentally and into milk. Spike protein binding antibody may be a feasible proxy for nAb.
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Source |
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| http://dx.doi.org/10.1038/s41372-023-01843-w | DOI Listing |
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