A highly efficient Ag(I)-catalyzed cascade Michael addition/cyclization of enynones with 1,3-(bis)diazo compounds has been established, providing functionalized 2,3-dihydrofuran derivatives containing a diazo group and an acetylenic bond with excellent diastereoselectivity. Transformation of the diazo group and hydration of the carbon-carbon triple bond have been performed successfully in different reaction systems.
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| http://dx.doi.org/10.1021/acs.joc.3c01527 | DOI Listing |
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