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Outcome after cytoreductive surgery combined with hyperthermic intrathoracic chemotherapy in patients with secondary pleural metastases. | LitMetric

AI Article Synopsis

  • The study explored the effectiveness of combining cytoreductive surgery with hyperthermic intrathoracic chemotherapy (CRS+HITOC) in patients with pleural metastases, focusing on overall survival and complications.
  • In a review of 31 patients, the majority were diagnosed with non-small cell lung cancer and achieved a high rate of complete tumor resection (90%), but had notable postoperative complications (35%) and a 10% mortality rate.
  • Results showed a median overall survival of 39 months, with better outcomes for those receiving additional chemotherapy, indicating that CRS+HITOC could be a viable treatment for carefully selected patients with secondary pleural metastases.

Article Abstract

Background: The role of cytoreductive surgery combined with hyperthermic intrathoracic chemotherapy (CRS+HITOC) for patients with secondary pleural metastases has scarcely been investigated.

Patients And Methods: We conducted a retrospective, multicentre study investigating the outcome of CRS+HITOC for 31 patients with pleural metastases from different primary tumours in four high-volume departments of thoracic surgery in Germany. The primary endpoint was overall survival (OS). Secondary endpoints included postoperative complications and recurrence/progression-free survival (RFS/PFS).

Results: The primary tumour was non-small cell lung cancer in 12 (39%), ovarian cancer in 5 (16%), sarcoma in 3 (10%), pseudomyxoma peritonei in 3 (10%), and others in 8 (26%) patients. A macroscopic complete resection (R/1) could be achieved in 28 (90%) patients. Major postoperative complications as classified by Clavien-Dindo (III-V) were observed in 11 (35%) patients. The postoperative mortality rate was 10% (n=3). A total of 13 patients received additive chemotherapy (42%). The median time of follow up was 30 months (95% CI = 17- 43). The median OS was 39 months (95% CI: 34-44 months) with 1-month, 3-month, 1-, 3-, and 5-year survival estimates of 97%, 89%, 77%, 66%, and 41%. There was a significantly prolonged OS in patients who received additive chemotherapy compared to patients with only CRS+HITOC (median OS 69 38 months; p= 0.048). The median RFS was 14 months (95% CI: 7-21 months).

Conclusions: We observed that CRS+HITOC is a feasible approach with reasonable complications and prolonged survival as a part of multimodal concept for highly selected patients with secondary pleural metastases.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715587PMC
http://dx.doi.org/10.3389/fonc.2023.1259779DOI Listing

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