An integrated analysis of related to malignant properties and immune infiltration of gliomas.

Background: is recognized as a proinflammatory molecule and activates the inflammatory response in multiple disorders. However, little has been reported on in glioma. This study sought to explore its expression, biological function, and association with clinical pathological indicators, prognosis, and immune infiltration levels in glioma through glioma cohorts.

Methods: A cohort of 657 patients was screened from the Chinese Glioma Genome Atlas (CGGA). test was performed to calculate the difference of classified variables. Cox proportional hazard regression modeling was used to identify independent prognostic indicators of glioma patients. A survival plot was generated by the Kaplan-Meier method. The immune cell infiltration score of glioma patients was calculated by TIMER algorithm.

Results: We observed that high expression of was strongly associated with malignant clinical indicators in 657 patients with glioma, and patients with high expression had worse prognoses. Multivariate Cox analysis showed that could be a new independent prognostic indicator for glioma patients. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that overexpression correlated with multiple inflammatory and immune biological processes. Additionally, high expression was strongly associated with higher abundance and marker gene expression of multiple tumor immune cells in low-grade glioma. Finally, a model was constructed to improve the prognostic evaluation of glioma patients.

Conclusions: The gene is highly expressed in gliomas and is significantly associated with clinical indicators of malignant progression in glioma patients. In glioma, patients with high expression displayed a worse outcome. In glioma tissues, the expression level of highly correlated with the abundance of tumor immune cell infiltration. Additionally, GO and KEGG enrichment analysis revealed that expression may be involved in a variety of immune and inflammatory biological processes.