Bacteriophages are expected to be therapeutic agents against infectious diseases. are involved in dental plaque formation related to dental caries and periodontitis. In , lytic bacteriophages have been isolated previously, but the isolation of temperate bacteriophage has not been reported although their presence in the genome has been confirmed. Here, we report the isolation of temperate bacteriophage, φKSM96, from . φKSM96 has a circular DNA 39,820 bp long and reveals Siphoviridae morphology. φKSM96 shows a broad range of susceptibility against strains with different serotypes. By the addition of φKSM96, growth and biofilm formation were significantly inhibited. In cocultures of with other bacterial species, the proportion of significantly decreased in the presence of φKSM96. In summary, φKSM96 shows selective anti- activity. The isolation of temperate bacteriophage is important for future genetic manipulation to create more efficient bacteriophages.
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| http://dx.doi.org/10.1016/j.isci.2023.108465 | DOI Listing |
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