IS drives the dissemination of genes in an Ecuadorian community.

The horizontal gene transfer events are the major contributors to the current spread of CTX-M-encoding genes, the most common extended-spectrum β-lactamase (ESBL), and many clinically crucial antimicrobial resistance (AMR) genes. This study presents evidence of the critical role of IS transposable element for the mobility of gene among isolates from children and domestic animals in the community. We suggest that the nucleotide sequences of IS- could be used to study transmission between humans, domestic animals, and the environment, because understanding of the dissemination patterns of AMR genes is critical to implement effective measures to slow down the dissemination of these clinically important genes.