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Differentiating Pulmonary Nodule Malignancy Using Exhaled Volatile Organic Compounds: A Prospective Observational Study.
Cancer Med
January 2025
Department of Health Management Center, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China.
Background: Advances in imaging technology have enhanced the detection of pulmonary nodules. However, determining malignancy often requires invasive procedures or repeated radiation exposure, underscoring the need for safer, noninvasive diagnostic alternatives. Analyzing exhaled volatile organic compounds (VOCs) shows promise, yet its effectiveness in assessing the malignancy of pulmonary nodules remains underexplored.
View Article and Find Full Text PDFIntroduction: Pancreatic cancer is one of the most aggressive tumors diagnosed in local-ly advanced or metastatic stage in more than half of the cases. The standard of care is a systemic chemotherapy but the prognosis of metastatic patients remains extremely poor with a median overall survival less than one year. However, there is increasing evidence of surgery treatment benefit in a carefully selected oligometastatic cases.
View Article and Find Full Text PDFRepeat laparoscopic hepatectomy versus radiofrequency ablation for recurrent hepatocellular carcinoma: A multicenter, propensity score matching analysis.
Biosci Trends
December 2024
Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Naval Military Medical University, Shanghai, China.
Article Synopsis
- This study compares the effectiveness of repeat laparoscopic hepatectomy (r-LH) and radiofrequency ablation (RFA) in treating patients with recurrent hepatocellular carcinoma (RHCC) based on clinical outcomes and survival rates.
- Data from 272 RHCC patients were analyzed, revealing that while RFA resulted in shorter hospital stays and fewer complications, r-LH significantly improved overall and disease-free survival rates.
- Particularly, patients with solitary tumors or those located near critical structures benefitted more from r-LH, especially when tumors were 5 cm or smaller, suggesting it as a more favorable treatment option in these cases.
The vagus nerve: An old but new player in brain-body communication.
Brain Behav Immun
November 2024
Chiba University Center for Forensic Mental Health, Chiba, Japan. Electronic address:
The vagus nerve is a crucial component of the parasympathetic nervous system, facilitating communication between the brain and various organs, including the ears, heart, lungs, pancreas, spleen, and gastrointestinal tract. The caudal nucleus of the solitary tract in the brainstem is the initial site regulated by the vagus nerve in brain-body communication, including the interactions with immune system. Increasing evidence suggests that the gut-brain axis, via the vagus nerve, may play a role in the development and progression of psychiatric, neurologic, and inflammation-related disorders.
View Article and Find Full Text PDFCXCL1-CXCR2 signaling mediates the activation of microglia in the nucleus tractus solitarii to promote pancreatic cancer-induced pain.
Brain Behav Immun
January 2025
Department of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. Electronic address:
Article Synopsis
- Pancreatic cancer can lead to severe abdominal pain, and while peripheral mechanisms have been explored, the involvement of the central nervous system, specifically the nucleus tractus solitarii (NTS), remains less understood.
- Researchers found that in mice experiencing pancreatic cancer-induced pain, neurons in the NTS showed increased activity and excitability, alongside signs of neuroinflammation and microglia activation.
- Intervention using a microglia inhibitor or blocking the CXCL1-CXCR2 signaling pathway significantly reduced pain symptoms, suggesting that the activation of microglia in the NTS plays a crucial role in mediating this pain response.*
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