Currently, the standard treatment for extremity high-risk soft tissue sarcomas (ESTS) combines surgery and pre- or post-op radiation therapy (RT). In some selected cases, chemotherapy (CT) is incorporated into the therapeutic algorithm as a neoadjuvant approach to enable conservative management. Given the risk of local or metastatic relapse, this paper discusses the potential benefits of CT and RT in high-grade ESTs. The role of adjuvant chemotherapy in addition to neoadjuvant CT, the prognostic value of the pathological response to neoadjuvant treatment, and the role for an adjuvant "boost" following resection after pre-operative radiotherapy will be discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12032-023-02240-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Reliability and validity of the Turkish version of the Infant Motor Activity Log in infants with upper extremity functional asymmetry: how often and how well?
Turk J Med Sci
December 2024
Cerebral Palsy and Pediatric Rehabilitation Unit, Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkiye.
Background/aim: Functional asymmetry in the upper extremities may occur in infants with neuromotor problems due to neurodevelopmental or musculoskeletal disorders. The aim of this study was to investigate the validity and reliability of the Turkish version of the Infant Motor Activity Log (IMAL-T), which assesses the frequency (how often) and quality (how well) of the affected arm usage during activities in infants with functional asymmetry in the upper extremities.
Materials And Methods: The IMAL-T was administered face-to-face to the parents of 102 infants [60 infants at high risk of developing cerebral palsy (CP) and 42 infants with brachial plexus birth injury (BPBI)], aged 6-24 months, with functional asymmetry in the upper extremities.
Decoding of pain during heel lancing in human neonates with EEG signal and machine learning approach.
Sci Rep
December 2024
Neuroscience & Neuroengineering Research Lab, Biomedical Engineering Department, School of Electrical Engineering, Iran University of Science & Technology (IUST), Narmak, Tehran, Iran.
Currently, pain assessment using electroencephalogram signals and machine learning methods in clinical studies is of great importance, especially for those who cannot express their pain. Since newborns are among the high-risk group and always experience pain at the beginning of birth, in this research, the severity of newborns has been investigated and evaluated. Other studies related to the annoyance of newborns have used the EEG signal of newborns alone; therefore, in this study, the intensity of newborn pain was measured using the electroencephalogram signal of 107 infants who were stimulated by the heel lance in three levels: no pain, low pain and moderate pain were recorded as a single trial and evaluated.
View Article and Find Full Text PDFSuperiority of Pathologic Lymph Node Ratio over Positive Lymph Node Count in Operated Early-Stage Breast Cancer.
Ann Ital Chir
December 2024
Department of General Surgery, Faculty of Medicine, Dicle University, 21280 Diyarbakır, Türkiye.
Aim: In early-stage breast cancer, the axillary lymph nodes play a crucial role in determining the prognosis of the disease. The rate of lymph node involvement might be a more valuable prognostic factor than the number of positive lymph nodes. Therefore, we aimed to evaluate whether the lymph node ratio (LNR) is a superior prognostic indicator compared to the pathologic lymph node count in early-stage disease.
View Article and Find Full Text PDFPreoperative hemoglobin level and anemia frequency among patients admitted for diabetic lower extremity amputation.
Vascular
December 2024
Department of Orthopedic Surgery, Lebanese American University Medical Center-Rizk Hospital, Lebanese American University, School of Medicine, Beirut, Lebanon.
Objectives: Anemia is known to be prevalent in patients with diabetic foot ulcers, but such was not documented in those who required lower extremity amputations (LEAs). In this high-risk population, preoperative anemia could be an additional risk factor for postoperative morbidity and mortality. This study attempts to address the knowledge gap related to the preoperative hemoglobin (Hg) level and anemia prevalence in patients admitted for diabetic LEA.
View Article and Find Full Text PDFDoes lower limb kinesio taping affect pain, muscle strength, and balance following fatigue in healthy subjects? A systematic review and meta analysis of parallel randomized controlled trials.
BMC Sports Sci Med Rehabil
December 2024
Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Background: Kinesio tape (KT) has gained popularity in sports and rehabilitation due to its ease of use and potential benefits. However, its effectiveness is not well understood especially in addressing fatigue, a condition that can impair muscle function and increase the musculoskeletal risk of injury. Given KT's potential impact on muscle activity and recovery, this review aims to evaluate the effects of lower limb KT on pain, strength, and balance following fatigue.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!