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Dementia Care Practice.

Alzheimers Dement

December 2024

Clinic of Cardiovascular Diseases named after Most Holy John Tobolsky, Moscow, Moscow, Russia.

Background: Most cerebrovascular lesions are aggravated by dementia. This study examines the possibility of reducing dementia by stimulating cerebral angiogenesis and neurogenesis using Transcatheter Intracerebral Laser Photobiomodulation Therapy (PBMT) in patients with Alzheimer's disease (AD), distal cerebral atherosclerosis, Binswanger's disease (BD), and vascular parkinsonism (VP).

Methods: The study included 404 patients with dementia, aged 29-81 (mean age 78).

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Article Synopsis
  • - Negative pressure breathing (NPBin) is a technique that lowers pressure in the respiratory tract during inhalation, aiming to boost blood flow to the heart and counteract fluid shifts in space.
  • - This study analyzed the effects of NPBin for 25 minutes at pressure reductions of -10 to -25 cmHO, using various non-invasive measurement techniques to assess changes in circulation and respiration in healthy volunteers.
  • - Results showed that NPBin increased tidal volume and decreased respiratory rate without significantly affecting overall minute ventilation, while circulatory parameters showed increased amplitude during breathing cycles, indicating a complex interaction between respiration and circulation.
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Sleep plays an essential role in physiology, allowing the brain and body to restore itself. Despite its critical role, our understanding of the underlying processes in the sleeping human brain is still limited. Sleep comprises several distinct stages with varying depths and temporal compositions.

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Objective: To identify the differences or comparability of parameters of cerebral hemodynamics between patients with schizophrenia with or without concomitant metabolic syndrome (MS).

Material And Methods: The study included 94 patients with schizophrenia (48 men and 46 women). A control group consisted of 40 mentally and somatically healthy individuals (17 men and 23 women) comparable in sex and age to the main group of patients.

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Cerebral blood flow (CBF) autoregulation (AR) can be monitored using invasive modalities, such as intracranial pressure (ICP) and arterial blood pressure (ABP) to calculate the CBF AR index (PRx). Monitoring PRx can reduce the extent of secondary brain damage in patients. Rheoencephalography (REG) is an FDA-approved non-invasive method to measure CBF.

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