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Endoscopic Versus Microscopic Stapedotomy: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Otolaryngol Head Neck Surg
January 2025
Department of Otolaryngology-Head and Neck Surgery, Jaber Al-Ahmed Hospital, Kuwait City, Kuwait.
Objective: To compare the safety and efficacy of endoscopic versus microscopic stapedotomy in patients with otosclerosis.
Data Sources: PubMed, Embase, Web of Science, Scopus, Google Scholar, and CENTRAL.
Review Methods: Eligible randomized controlled trials (RCTs) were assessed for bias using Cochrane's instrument.
Pathogenesis and management of -related Olmsted syndrome.
Front Genet
December 2024
Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, China.
Olmsted syndrome is characterized by symmetrically distributed, destructive, inflammatory palmoplantar keratoderma with periorificial keratotic plaques, most commonly due to gain-of-function mutations in the transient receptor potential vanilloid 3 (TRPV3) gene, which involves multiple pathological functions of the skin, such as hyperkeratosis, dermatitis, hair loss, itching, and pain. Recent studies suggest that mutations of located in different structural domains lead to cases of varying severity, suggesting a potential genotype-phenotype correlation resulting from TRPV3 gene mutations. This paper reviews the genetics and pathogenesis of Olmsted syndrome, as well as the potential management and treatment.
View Article and Find Full Text PDFThe determination of patient-based experiences with smartphone-based report of awake bruxism using a diary.
Clin Oral Investig
January 2025
Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Objectives: In recent years, a smartphone-based ecological momentary assessment (EMA) approach for assessing awake bruxism (AB) has attracted growing interest, both in clinical and research settings. The present study was designed to investigate subjects' experience using an EMA-based smartphone application to detect factors that could hamper or facilitate its use for clinical and research purposes.
Materials And Methods: Thirty-two patients with temporomandibular disorders (TMDs) pain (14 males, 18 females; mean age 28.
Mediators and Moderators of two online interventions for managing pain, fear of progression and functional ability in rheumatoid arthritis.
Behav Res Ther
December 2024
School of Psychological Sciences, Macquarie University, Sydney, NSW, Australia.
This is a secondary analysis of a trial comparing online mindfulness-based stress reduction with cognitive-behaviour therapy for people with rheumatoid arthritis. Both interventions were administered over eight weeks with five lessons and accompanied by weekly therapist contact. For the purposes of this study, we investigated the pain severity, fear of progression and functional ability as the outcome variables because the treatments had differential effects on these three outcomes but had equivalent effects on other variables.
View Article and Find Full Text PDFVenous Endothelial Cell Transcriptomic Profiling Implicates METAP1 in Preeclampsia.
Circ Res
December 2024
Cardiovascular Research Center, Massachusetts General Hospital, Boston. (C.C., P.X., Z.Y., Y.S., E.S.L., J.D.R., M.C.H.).
Background: Preeclampsia is a hypertensive disorder of pregnancy characterized by systemic endothelial dysfunction. The pathophysiology of preeclampsia remains incompletely understood. This study used human venous endothelial cell (EC) transcriptional profiling to investigate potential novel mechanisms underlying EC dysfunction in preeclampsia.
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