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Drug-induced enterocolitis, a new condition under consideration.
Allergol Immunopathol (Madr)
January 2025
Pediatric Allergy and Pulmonology Unit, Children's University Hospital Reina Sofia, Cordoba, Spain;
Drug-induced enterocolitis syndrome (DIES), little known due to its recent description, is analogous to food protein-induced enterocolitis syndrome (FPIES). Both processes are more frequent in pediatric age and share diagnostic criteria, the main one being the appearance of persistent vomiting 1-4 hours after ingestion of the drug or food, in the absence of IgE-mediated allergy symptoms.
View Article and Find Full Text PDFMycofenolate-induced ileocolitis.
Rev Esp Enferm Dig
September 2024
Gastroenterology , Centro Hospitalar e Universitário de Coimbra, Unidade de Saúde Local de Coimbra, Portugal.
Terminal ileitis is a common finding in clinical practice and is often associated with Crohn's disease. However, other pathologies must be considered particularly those resulting from side effects of drugs. We report a case of an 18-year-old female that underwent renal transplant under mycophenolate sodium, tacrolimus, and prednisolone admitted for abdominal pain, diarrhea and weight loss.
View Article and Find Full Text PDFReview article: Contemporary management of gastrointestinal, pancreatic and hepatic toxicities of immune checkpoint inhibitors.
Aliment Pharmacol Ther
June 2024
Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Article Synopsis
- Immune checkpoint inhibitors (ICIs) are effective cancer treatments but can lead to immune-related adverse events (irAEs) affecting multiple organs, particularly in the gastrointestinal and hepatic systems.
- A review of recent literature on these toxicities emphasizes the need for gastroenterologists to identify and manage conditions like enterocolitis, hepatitis, and others, using strategies from relevant oncology guidelines.
- The management of irAEs involves assessing severity, ruling out other causes, and employing treatments such as corticosteroids and immunosuppressants, but clinical guidelines are primarily based on retrospective data.
Direct oral challenge for immediate and non-immediate beta-lactam allergy in children: A real-world multicenter study.
Pediatr Allergy Immunol
March 2024
Hospital Universitario Miguel Servet, Zaragoza, Spain.
Article Synopsis
- - The study explored the use of Direct Oral Drug Provocation Test (DODPT) to safely assess beta-lactam antibiotic (BLA) allergies in children, revealing that over 90% of suspected cases could be ruled out effectively.
- - It involved 2,133 young patients across 15 hospitals in Spain, noting that most had mild reactions; only a handful experienced severe reactions, such as anaphylaxis, which resolved quickly with treatment.
- - The results suggest that DODPT is a reliable method for confirming or denying BLA allergies, making it a practical option for doctors in pediatric care to help "delabel" unnecessary allergies.
Clinical Management of Gastrointestinal and Liver Toxicities of Immune Checkpoint Inhibitors.
Clin Colorectal Cancer
March 2024
Department of Clinical Oncology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR, China; Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR, China; Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address:
Immune checkpoint inhibitors have transformed the treatment paradigm for various types of cancer. Nonetheless, with the utilization of these groundbreaking treatments, immune-related adverse events (irAEs) are increasingly encountered. Colonic and hepatic involvement are among the most frequently encountered irAEs.
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