AI Article Synopsis
- Multiple System Atrophy (MSA) is a neurodegenerative disease characterized by motor and autonomic symptoms, with a focus on the role of serotonin metabolism through the measurement of 5-HIAA levels in cerebrospinal fluid (CSF).
- A study compared CSF 5-HIAA levels between 69 MSA patients and 33 healthy controls, finding significantly lower levels in MSA patients, particularly those with probable MSA compared to possible MSA.
- The results indicate that lower CSF 5-HIAA levels correlate with more severe clinical symptoms in MSA, affecting daily activities, walking, and body stability.
Article Abstract
Background And Purpose: Multiple system atrophy (MSA) is a neurodegenerative disease with characteristic motor and autonomic symptoms. Impaired brain serotonergic innervation can be associated with various clinical indices of MSA; however, the relationship between clinical symptoms and cerebrospinal fluid (CSF) levels of 5-hydroxyindole acetic acid (5-HIAA), a main serotonin metabolite, has not been fully elucidated.
Methods: To compare CSF 5-HIAA levels between patients with MSA and healthy controls, we included 33 controls and 69 MSA patients with either predominant parkinsonian or cerebellar ataxia subtypes. CSF 5-HIAA levels were measured using high-performance liquid chromatography. Additionally, we investigated correlations between CSF 5-HIAA and various clinical indices in 34 MSA patients.
Results: CSF 5-HIAA levels were significantly lower in MSA patients than in controls (p < 0.0001). Probable MSA patients had lower CSF 5-HIAA levels than possible MSA patients (p < 0.001). In MSA patients, CSF 5-HIAA levels were inversely correlated with scores in Parts 1, 2, and 4 of the Unified Multiple System Atrophy Rating Scale, and with systolic and diastolic blood pressure in Part 3. Structural equation modeling revealed significant paths between serotonin and clinical symptoms, and significance was highest for activities of daily living, walking, and body sway.
Conclusions: Serotonin dysfunction, as assessed by CSF 5-HIAA levels, may implicate greater MSA severity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235942 | PMC |
| http://dx.doi.org/10.1111/ene.16158 | DOI Listing |
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