Neuromuscular electrical stimulation is used to improve the motor function of paralyzed limbs and prevent muscle atrophy in stroke patients. The system for electrical stimulation is broadly classified into current-mode stimulators and voltage-mode stimulators. The current-mode stimulator adjusts the amplitude of the current, whereas the amplitude of the voltage is adjusted for voltage-mode stimulators. Voltagemode stimulators have the advantage that there is little risk of burns even if the electrode is partially detached. To perform arbitrary current-mode stimulation with voltage-mode stimulators, it is necessary to generate a stimulating voltage based on the skin impedance. As a primary experiment, the frequency characteristics of the electrode-skin impedance were measured using an impedance analyzer on 6 subjects, and the frequency band in which the skin impedance is equivalent to a parallel connection between resistance and capacitance was determined. A prototype bridge circuit with a skin impedance equivalent circuit implemented was designed, assembled, and tested to estimate the skin impedances of 3 subjects. The residuals were computed from the estimated skin-impedance resistance and capacitance of the bridge circuit, and the impedance-analyzer-measured resistance and capacitance. The residuals between the estimated and measured were up to 4.4 % in the resistance component, and up to 8.2 % in the capacitance component of the skin impedance measurements by the impedance analyzer.
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http://dx.doi.org/10.1109/EMBC40787.2023.10340064 | DOI Listing |
Iran J Basic Med Sci
January 2025
Tissue Engineering and stem cells research center, Shahroud University of Medical Sciences, Shahroud, Iran.
Objectives: For designing a suitable hydrogel, two crosslinked Alginate/ Carboxymethyl cellulose (Alg/CMC) hydrogel, using calcium chloride (Ca) and glutaraldehyde (GA) as crosslinking agents were synthesized and compared.
Materials And Methods: All samples were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Blood compatibility (BC), Blood clotting index (BCI), weight loss (WL), water absorption (WA), pH, and Electrochemical Impedance Spectroscopy (EIS). Cell viability and cell migration were investigated using the MTT assay and the wound scratch test, respectively.
Anal Methods
January 2025
ampere - Laboratório de Plataformas Eletroquímicas - Universidade Federal de Santa Catarina, Departamento de Química, 88040-900 Florianópolis, SC, Brazil.
Terbinafine hydrochloride (TBF) is a broad-spectrum antifungal used to treat various dermatophyte infections affecting the skin, hair, and nails. Accurate, sensitive, and affordable analytical methods are crucial for quantifying this drug. In this study, we report on the use of carbon-based electrodes for the electrochemical determination of TBF in pharmaceutical samples, including raw materials and tablets.
View Article and Find Full Text PDFBiosens Bioelectron
January 2025
College of Mathematical Medicine, Zhejiang Normal University, Jinhua, China; Affiliated Dongyang Hospital of Wenzhou Medical University, Jinhua, China. Electronic address:
Microsyst Nanoeng
January 2025
Shien-Ming Wu School of Intelligent Engineering, South China University of Technology, Guangzhou, 511442, P. R. China.
Surface electromyogram (sEMG) serves as a means to discern human movement intentions, achieved by applying epidermal electrodes to specific body regions. However, it is difficult to obtain high-fidelity sEMG recordings in areas with intricate curved surfaces, such as the body, because regular sEMG electrodes have stiff structures. In this study, we developed myoelectrically sensitive hydrogels via 3D printing and integrated them into a stretchable, flexible, and high-density sEMG electrodes array.
View Article and Find Full Text PDFArch Dermatol Res
January 2025
Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
We have recently shown that fluoxetine (FX) suppressed polyinosinic-polycytidylic acid-induced inflammatory response and endothelin release in human epidermal keratinocytes, via the indirect inhibition of the phosphoinositide 3-kinase (PI3K)-pathway. Because PI3K-signaling is a positive regulator of the proliferation, in the current, highly focused follow-up study, we assessed the effects of FX (14 µM) on the proliferation and differentiation of human epidermal keratinocytes. We found that FX exerted anti-proliferative actions in 2D cultures (HaCaT and primary human epidermal keratinocytes [NHEKs]; 48- and 72-h; CyQUANT-assay) as well as in 3D reconstructed epidermal equivalents (48-h; Ki-67 immunohistochemistry).
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