Falls are among the most devastating events that can happen to an older person. Automatic fall detection systems aim to solve this problem by alerting carers and family the moment a fall occurs. This paper presents the development of an unobtrusive fall detection system using ultra-wideband (UWB) radar. The proposed system employed a ceiling-mounted UWB radar to avoid object occlusion and allow for flexible implementation. An innovative pre-processing method was developed to effectively enhance motion and reduce noise from raw UWB data. We designed a trial protocol composed of common types of falls in older population and activities of daily living (ADL). A fall detection algorithm based on convolutional neural networks was developed with simulated falls and ADLs obtained from ten participants following the trial protocol in a clear and cluttered living environment. The fall detection system achieved an accuracy of 93.97%, with a sensitivity of 95.58% and specificity of 92.68%.
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http://dx.doi.org/10.1109/EMBC40787.2023.10341081 | DOI Listing |
Alzheimers Dement
December 2024
Emory University School of Medicine, Atlanta, GA, USA.
Background: Early stages of Alzheimer's disease (AD) are characterized by neuropsychiatric symptoms such as anxiety, apathy, compulsivity, and sleep disturbances, which manifest years before cognitive deficits. It has been hypothesized that dysregulation of the locus coeruleus-norepinephrine (LC-NE) system contributes to these symptoms because (1) the LC is the first site where hyperphosphorylated 'pretangle' tau can be detected in the human brain and (2) NE influences physiological processes such as mood, stress responses, and arousal. To investigate causal relationships between LC tau pathology and neuropsychiatric symptoms, we developed a translationally-relevant model where pathogenic tau is exclusively expressed in mouse LC to recapitulate the 'LC-first' phenomenon.
View Article and Find Full Text PDFBackground: Fall-related mild traumatic brain injuries (mTBI) are prevalent among older adults and are a predictor of dementia. Delays in diagnoses lead to prolonged symptoms and impairments. Dual-task posture may be more sensitive to detecting impairments compared to single-task posture, but research is limited.
View Article and Find Full Text PDFAlzheimers Dement (N Y)
November 2024
Alzheimer's Association Chicago Illinois USA.
Unlabelled: The Alzheimer's disease (AD) research community continues to make great strides in expanding approaches for early detection and treatment of the disease, including recent advances in our understanding of fundamental AD pathophysiology beyond the classical targets: beta-amyloid and tau. Recent clinical trial readouts implicate a variety of non-amyloid/non-tau (NANT) approaches that show promise in slowing cognitive decline for people with AD. The Alzheimer's Association Research Roundtable (AARR) meeting held on December 13-14, 2022, reviewed the current state of NANT targets on underlying AD pathophysiology and their contribution to cognitive decline, the current data on a diverse range of NANT biomarkers and therapeutic targets, and the integration of NANT concepts in clinical trial designs.
View Article and Find Full Text PDFPlant Dis
December 2024
Department of Plant Protection, Biotechnical Faculty, University of Montenegro, 81000 Podgorica, Montenegro.
This collaborative work by over 180 researchers from 40+ countries addresses the challenges posed by "phantom agents"-putative pathogenic agents named in literature without supporting data on their existence. Those agents remain on regulatory lists, creating barriers in trade and plant certification. Historically identified based solely on symptoms, these agents lack isolates or sequence data, making reliable detection or risk assessment impossible.
View Article and Find Full Text PDFNeurourol Urodyn
December 2024
Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Introduction: Detrusor contractions can be classified as either volitional or involuntary. The latter are a hallmark of urge urinary incontinence. Understanding differences in neuroactivation associated with both types of contractions can help elucidate pathophysiology and therapeutic targets.
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