The relationship between externally applied force and intraocular pressure was determined using an ex-vivo porcine eye model (N=9). Eyes were indented through the sclera with a convex ophthalmodynamometry head (ODM). Intraocular pressure and ophthalmodynamometric force were simultaneously recorded to establish a calibration curve of this indenter head. A calibration coefficient of 0.140 ± 0.009 mmHg/mN was established and was shown to be highly linear (r = 0.998 ± 0.002). Repeat application of ODM resulted in a 0.010 ± 0.002 mmHg/mN increase to the calibration coefficient.Clinical Relevance- ODM has been highlighted as a potential method of non-invasively estimating intracranial pressure. This study provides relevant data for the practical performance of ODM with similar compressive devices.
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http://dx.doi.org/10.1109/EMBC40787.2023.10340233 | DOI Listing |
Sci Rep
January 2025
Affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, 214151, Jiangsu, China.
Objective: Construction a troublemaking risk assessment tool to predict the risk of troublemaking for patients with severe mental disorders in the community of China.
Methods: 28,000 cases registered in the Jiangsu Provincial Severe Mental Disorder Management System from January 2017 to December 2019 were collected. The risk factors of troublemaking among patients with severe mental disorders in the community were analyzed through Logistic regression analysis, then the troublemaking risk assessment tool was established and verified.
Acad Radiol
January 2025
Department of Radiology, Shengjing Hospital of China Medical University, China (Y.Y., T.W.). Electronic address:
Rationale And Objectives: Mixed ground-glass nodules (mGGNs) are highly malignant and common nonspecific lung imaging findings. This study aimed to explore whether combining quantitative and qualitative spectral dual-layer detector-based computed tomography (SDCT)-derived parameters with serological tumor abnormal proteins (TAPs) and thymidine kinase 1 (TK1) expression enhances invasive mGGN diagnostic efficacy and to develop a joint diagnostic model.
Materials And Methods: This prospective study included patients with mGGNs undergoing preoperative triple-phase contrast-enhanced SDCT with TAP and TK1 tests.
Acad Radiol
January 2025
Department of Radiology, Southeast University Zhongda Hospital, No. 87 Dingjiaqiao Road, Gulou District, Nanjing, Jiangsu Province, China (M.Y., J.J.). Electronic address:
Rationale And Objectives: To develop radiomics and deep learning models for differentiating malignant and benign soft tissue tumors (STTs) preoperatively based on fat saturation T2-weighted imaging (FS-T2WI) of patients.
Materials And Methods: Data of 115 patients with STTs of extremities and trunk were collected from our hospital as the training set, and data of other 70 patients were collected from another center as the external validation set. Outlined Regions of interest included the intratumor and the peritumor region extending outward by 5 mm, then the corresponding radiomics features were extracted respectively.
J Med Internet Res
December 2024
Department of Medical Informatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China.
Background: Primary hypertension (PH) poses significant risks to children and adolescents. Few prediction models for the risk of PH in children and adolescents currently exist, posing a challenge for doctors in making informed clinical decisions.
Objective: This study aimed to investigate the incidence and risk factors of PH in Chinese children and adolescents.
Cancer Control
January 2025
Department of Oncology, Suining Central Hospital, Suining, China.
Objective: Our study aimed to update demographic profiles of sinonasal adenocarcinoma (SNAC) between 2000 and 2020, identify independent prognostic risk factors, and devise a predictive nomogram for overall survival (OS).
Methods: Utilizing the Surveillance, Epidemiology, and End Results (SEER) database, cases of SNAC from 2000 to 2020 were analyzed for incidence trends. Univariate and multivariate Cox regression models helped pinpoint factors impacting patient survival.
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