AI Article Synopsis
- Chronic inflammation from inflammatory bowel disease can lead to colitis-associated colorectal cancer (CACRC), which is linked to oxidative stress and inflammation.
- A study tested a series of gold(III) complexes (TGS 121, 404, 512, 701, 702, and 703) on both cancerous and normal colon cell lines, as well as in a mouse model of CACRC.
- TGS 121, 404, and 702 showed the most promise for reducing tumors and inflammation, suggesting their potential as new treatments for colorectal cancer.
Article Abstract
Background: Chronic inflammation in the course of inflammatory bowel disease may result in colon cancer, or colitis-associated colorectal cancer (CACRC). It is well established that CACRC is associated with oxidative stress and secretion of multiple pro-inflammatory cytokines, e.g. tumor necrosis factor-α. Recently, we proved that the administration of gold(III) complexes resulted in the alleviation of acute colitis in mice. The aim of the current study was to assess the antitumor effect of a novel series of gold(III) complexes: TGS 121, 404, 512, 701, 702, and 703.
Materials: Analyzed gold(III) complexes were screened in the in vitro studies using colorectal cancer and normal colon epithelium cell lines, SW480, HT-29, and CCD 841 CoN, and in vivo, in the CACRC mouse model.
Results: Of all tested complexes, TGS 121, 404, and 702 exhibited the strongest anti-tumor effect in in vitro viability assay of colon cancer cell lines and in in vivo CACRC model, in which these complexes decreased the total number of colonic tumors and macroscopic score. We also evidenced that the mechanism of action was linked to the enzymatic antioxidant system and inflammatory cytokines.
Conclusions: TGS 121, 404, and 702 present anti-tumor potential and are an attractive therapeutic option for colorectal cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10830623 | PMC |
| http://dx.doi.org/10.1007/s43440-023-00558-1 | DOI Listing |
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