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Cobaltaelectro-Catalyzed C-H Annulation with Allenes for Atropochiral and -Stereogenic Compounds: Late-Stage Diversification and Continuous Flow Scale-Up. | LitMetric

The 3d metallaelectro-catalyzed C-H activation has been identified as an increasingly viable strategy to access valuable organic molecules in a resource-economic fashion under exceedingly mild reaction conditions. However, the development of enantioselective 3d metallaelectro-catalyzed C-H activation is very challenging and in its infancy. Here, we disclose the merger of cobaltaelectro-catalyzed C-H activation with asymmetric catalysis for the highly enantioselective annulation of allenes. A broad range of C-N axially chiral and -stereogenic compounds were thereby obtained in good yields of up to 98% with high enantioselectivities of up to >99% ee. The practicality of this approach was demonstrated by the diversification of complex bioactive compounds and drug molecules as well as decagram scale enantioselective electrocatalysis in continuous flow.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10704562PMC
http://dx.doi.org/10.1021/acscatal.3c02072DOI Listing

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