AI Article Synopsis
- - PTLD is a serious complication that can occur after solid organ or stem cell transplants, characterized by rapid progression and high mortality, making it a significant threat to long-term survival of transplant recipients.
- - The disorder involves the abnormal growth of lymphocytes, which leads to complex and non-specific symptoms, complicating diagnosis and treatment.
- - A retrospective study of two PTLD patients analyzed their medical histories, symptoms, treatments, and outcomes to enhance understanding and awareness of PTLD in hematology and oncology.
Article Abstract
As one of the worst complications after solid organ transplantation (SOT) or hematopoietic stem cell transplantation (HSCT), post-transplant lymphoproliferative disorder (PTLD) usually progresses rapidly and accompanies with a high mortality rate, which is the most notorious adverse event threatening long-term survival of organ transplant recipients. PTLD is generally characterized by malignant clonal proliferation of lymphocytes, so the location of the disease is uncertain, the clinical symptoms and signs are very complex, lack of specificity, and it is easy to miss diagnosis and misdiagnosis in clinical practice, which will lead to low survival of patients after transplantation. To this end, the clinical data of two patients with PTLD were retrospectively studied, and characteristics of medical history, clinical manifestations, treatment process, curative effect and prognosis of the patients with PTLD were systematically analyzed and discussed, with a view to improving the novel understanding of PTLD in the field of hematology and oncology.
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