AI Article Synopsis
- Dysregulation of epithelial-mesenchymal transition (EMT) in the airway epithelium contributes to airway remodeling and worsening pulmonary fibrosis in conditions like asthma and COPD.
- Research indicates that certain treatments can effectively inhibit EMT and reduce pulmonary fibrosis progression with minimal side effects.
- The review explores the mechanisms of airway remodeling via EMT, therapeutic targets for intervention, and available drugs—including herbal compounds and inhibitors—that may aid in suppressing these harmful processes.
Article Abstract
. Dysregulation of epithelial-mesenchymal transition (EMT) in the airway epithelium is associated with airway remodeling and the progression of pulmonary fibrosis. Many treatments have been shown to inhibit airway remodeling and pulmonary fibrosis progression in asthma and chronic obstructive pulmonary disease (COPD) by regulating EMT and have few side effects. This review aimed to describe the development of airway remodeling through the EMT pathway, as well as the potential therapeutic targets in these pathways. Furthermore, this study aimed to review the current research on drugs to treat airway remodeling and their effects on the EMT pathway. . The dysregulation of EMT was associated with airway remodeling in various respiratory diseases. The cytokines released during inflammation may induce EMT and subsequent airway remodeling. Various drugs, including herbal formulations, specific herbal compounds, cytokines, amino acid or protein inhibitors, microRNAs, and vitamins, may suppress airway remodeling by inhibiting EMT-related pathways.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701063 | PMC |
| http://dx.doi.org/10.1155/2023/3291957 | DOI Listing |
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